ArticleMagnetic resonance in medicine2019
Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Physiological Interpretation of the Lactate to Pyruvate AUC Ratio for Hyperpolarized [1-Magnetic resonance in medicine · 2026Article
- Pharmacokinetic modeling strategies for dynamic hyperpolarized urea imaging.Magnetic resonance in medicine · 2026Article
- Optimal Variable Flip Angle Schemes for Hyperpolarized MR Kinetic Modeling Robust to RF Field Variations.NMR in biomedicine · 2025Article
- A flexible MRF approach to improve kinetic rate estimation with bSSFP-based hyperpolarized [1-Magnetic resonance in medicine · 2025Article
- [Research Progress in Applying HyperpolarizedSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- First-in-Human Hyperpolarized MRI for Tumor Metabolism in HNSCC.JAMA otolaryngology-- head & neck surgery · 2024Article
- Model-constrained reconstruction accelerated with Fourier-based undersampling for hyperpolarized [1-Magnetic resonance in medicine · 2023Article
- Metabolite-Specific Echo Planar Imaging for Preclinical Studies with HyperpolarizedTomography (Ann Arbor, Mich.) · 2023Article
- Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarizedScientific reports · 2023Article
- Specialized computational methods for denoising, BMagnetic resonance in medicine · 2021Article
- CardiacMagnetic resonance in medicine · 2021Article
- Review
- HyperpolarizedNMR in biomedicine · 2021Article
- Fast Imaging for Hyperpolarized MR Metabolic Imaging.Journal of magnetic resonance imaging : JMRI · 2021Review
- Slice profile effects on quantitative analysis of hyperpolarized pyruvate.NMR in biomedicine · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeVarious excitation strategies have been proposed for dynamic imaging of hyperpolarized agents such as [1-
methodsSignal evolution for constant and variable excitation angle schedules was simulated using a pharmacokinetic model of hyperpolarized pyruvate with 2 chemical pools and 2 physical compartments. Noisy synthetic data were then fit using the same pharmacokinetic model with the apparent chemical exchange term as an unknown, and fit results were compared with simulation parameters to determine accuracy and reproducibility.
resultsConstant excitations and a variable excitation strategy that maximizes the HP lactate signal yielded data that supported quantitative analyses with similar accuracy and repeatability. Variable excitation angle strategies that were designed to produce a constant signal level resulted in lower signal and worse quantitative accuracy and repeatability, particularly for longer acquisition times.
conclusionsThese results suggest that either constant excitation angle or variable excitation angles that attempt to maximize total signal, as opposed to maintaining a constant signal level, are preferred for metabolic quantification using hyperpolarized pyruvate.
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