ArticleJournal of biomedical optics2019
Development of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Dissecting oral premalignant carcinogenesis: spatial omics mechanisms and nanomedicine-driven therapeutic innovation.Molecular cancer · 2026Review
- Development and Evaluation of an Automated Multimodal Mobile Detection of Oral Cancer Imaging System to Aid in Risk-Based Management of Oral Mucosal Lesions.Cancer prevention research (Philadelphia, Pa.) · 2025Article
- Recent advance in early oral lesion diagnosis: the application of artificial intelligence-assisted endoscopy.Frontiers in oncology · 2025Review
- Use of topical methylene blue to image nuclear morphometry with a low-cost scanning darkfield microendoscope.Journal of biomedical optics · 2024Article
- Single source CARS-based multimodal microscopy system for biological tissue imaging [Invited].Biomedical optics express · 2024Article
- Review
- Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment.Journal of biomedical optics · 2023Article
- Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions.Oral oncology · 2022Article
- Multimodal microscopy for the simultaneous visualization of five different imaging modalities using a single light source.Biomedical optics express · 2021Article
- Bimodal multispectral imaging system with cloud-based machine learning algorithm for real-time screening and detection of oral potentially malignant lesions and biopsy guidance.Journal of biomedical optics · 2021Article
- High frame rate video mosaicking microendoscope to image large regions of intact tissue with subcellular resolution.Biomedical optics express · 2021Article
- Multimodal widefield fluorescence imaging with nonlinear optical microscopy workflow for noninvasive oral epithelial neoplasia detection: a preclinical study.Journal of biomedical optics · 2020Article
- Algorithm to quantify nuclear features and confidence intervals for classification of oral neoplasia from high-resolution optical images.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Repurposing Molecular Imaging and Sensing for Cancer Image-Guided Surgery.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Review
- Prospective evaluation of oral premalignant lesions using a multimodal imaging system: a pilot study.Head & neck · 2020Article
- Autofluorescence Imaging to Monitor the Progression of Oral Potentially Malignant Disorders.Cancer prevention research (Philadelphia, Pa.) · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Oral premalignant lesions (OPLs), such as leukoplakia, are at risk of malignant transformation to oral cancer. Clinicians can elect to biopsy OPLs and assess them for dysplasia, a marker of increased risk. However, it is challenging to decide which OPLs need a biopsy and to select a biopsy site. We developed a multimodal optical imaging system (MMIS) that fully integrates the acquisition, display, and analysis of macroscopic white-light (WL), autofluorescence (AF), and high-resolution microendoscopy (HRME) images to noninvasively evaluate OPLs. WL and AF images identify suspicious regions with high sensitivity, which are explored at higher resolution with the HRME to improve specificity. Key features include a heat map that delineates suspicious regions according to AF images, and real-time image analysis algorithms that predict pathologic diagnosis at imaged sites. Representative examples from ongoing studies of the MMIS demonstrate its ability to identify high-grade dysplasia in OPLs that are not clinically suspicious, and to avoid unnecessary biopsies of benign OPLs that are clinically suspicious. The MMIS successfully integrates optical imaging approaches (WL, AF, and HRME) at multiple scales for the noninvasive evaluation of OPLs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.