Evidence map›Paper›PMID 30793410›Full record

ArticleHuman brain mapping2019

Network abnormalities among non-manifesting Parkinson disease related LRRK2 mutation carriers.

Yael Jacob, Keren Rosenberg-Katz, Tanya Gurevich, Rick C Helmich, Bastiaan R Bloem, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman, Talma Hendler, Avner Thaler

Open access · bronzeAbstract read
In one paragraph

Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The pathobiological basis of depression in Parkinson disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Functional Connectome in Parkinson's Disease and Parkinsonism.Current neurology and neuroscience reports · 2021
    Review
  12. Genetic and Environmental Factors Influence the Pleomorphy ofInternational journal of molecular sciences · 2021
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Yael JacobTranslational and Molecular Imaging Institute, Icahn School of Medicine, Mount Sinai Medical Center, New York, New York.
Keren Rosenberg-KatzSagol Brain Institute Tel-Aviv Medical Center, Tel-Aviv, Israel.
Tanya GurevichSagol Brain Institute Tel-Aviv Medical Center, Tel-Aviv, Israel.
Rick C HelmichDonders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
Bastiaan R BloemDonders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
Avi Orr-UrtregerSackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Nir GiladiSagol Brain Institute Tel-Aviv Medical Center, Tel-Aviv, Israel.
Anat MirelmanSagol Brain Institute Tel-Aviv Medical Center, Tel-Aviv, Israel.
Talma HendlerSagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
Avner ThalerSagol Brain Institute Tel-Aviv Medical Center, Tel-Aviv, Israel.ORCID 0000-0001-7629-8120
Tel Aviv University · ILRadboud University Nijmegen · NL

Funding

Michael J. Fox Foundation for Parkinson's Research
6 · The paper itself

Abstract

Non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene represent an "at risk" group for future development of Parkinson's disease (PD) and have demonstrated task related fMRI changes. However, resting-state networks have received less research focus, thus this study aimed to assess the integrity of the motor, default mode (DMN), salience (SAL), and dorsal attention (DAN) networks among this unique population by using two different connectivity measures: interregional functional connectivity analysis and Dependency network analysis (D

Indexed as

ConnectomeMachine LearningAdultCerebrumFemaleHeterozygoteHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Magnetic Resonance ImagingMaleMiddle AgedNerve NetParkinson DiseaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humangraph theory network analysisLRRK2machine learning classificationParkinson's diseaseresting state fMRI

Identifiers

PMID30793410
PMCPMC6865680
OpenAlexW2915382619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.