Evidence map›Paper›PMID 30793241›Full record

ArticleMolecular imaging and biology2019

Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer: First Experience in a Canine Prostate Cancer Model.

Sunitha V Bachawal, Jae Mo Park, Keerthi S Valluru, Mathias Dyrberg Loft, Stephen A Felt, José G Vilches-Moure, Yamil F Saenz, Bruce Daniel, Andrei Iagaru, Geoffrey Sonn and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Review
  5. [European journal of nuclear medicine and molecular imaging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sunitha V BachawalDepartment of Radiology, Stanford University, Stanford, CA, USA.
Jae Mo ParkDepartment of Radiology, Stanford University, Stanford, CA, USA.
Keerthi S ValluruDepartment of Radiology, Stanford University, Stanford, CA, USA.
Mathias Dyrberg LoftDepartment of Radiology, Stanford University, Stanford, CA, USA.
Stephen A FeltDepartment of Comparative Medicine, Stanford University, Stanford, CA, USA.
José G Vilches-MoureDepartment of Comparative Medicine, Stanford University, Stanford, CA, USA.
Yamil F SaenzDepartment of Comparative Medicine, Stanford University, Stanford, CA, USA.
Bruce DanielDepartment of Radiology, Stanford University, Stanford, CA, USA.
Andrei IagaruDepartment of Radiology, Stanford University, Stanford, CA, USA.
Geoffrey SonnDepartment of Radiology, Stanford University, Stanford, CA, USA.
Zhen ChengDepartment of Radiology, Stanford University, Stanford, CA, USA.
Daniel M SpielmanDepartment of Radiology, Stanford University, Stanford, CA, USA.
Jürgen K WillmannDepartment of Radiology, Stanford University, Stanford, CA, USA. willmann@stanford.edu.

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
6 · The paper itself

Abstract

purposeTo assess whether simultaneous hyperpolarized C-13 magnetic resonance spectroscopy (MRS)/positron emission tomography (PET)/multiparametric magnetic resonance (mpMR) imaging is feasible in an orthotopic canine prostate cancer (PCa) model using a clinical PET/MR system and whether the combined imaging datasets can be fused with transrectal ultrasound (TRUS) in real time for multimodal image fusion-guided targeted biopsy of PCa. PROCEDURES: Institutional Animal Care and Use Committee approval was obtained for this study. Canine prostate adenocarcinoma (Ace-1) cells were orthotopically injected into the prostate of four dogs. Once tumor engraftment was confirmed by TRUS, simultaneous hyperpolarized C-13 MRS of [1-

resultsSuccessful tumor engraftment was histologically confirmed in three of the four dogs (dogs 2, 3, and 4) and simultaneous C-13 MRS/PET/mpMR was feasible in all three. In dog 2, C-13 MRS showed increased lactate signal in the tumor (lactate/totalC = 0.47) whereas mpMR did not show any signal changes. In dog 3, [

conclusionSimultaneous C-13 MRS/PET/mpMR imaging and multimodal image fusion-guided biopsy is feasible in a canine PCa model.

Indexed as

Carbon-13 Magnetic Resonance SpectroscopyImage-Guided BiopsyMultimodal ImagingMultiparametric Magnetic Resonance ImagingPositron-Emission TomographyAnimalsDisease Models, AnimalDogsImage Processing, Computer-AssistedMalePhantoms, ImagingProstateProstatic NeoplasmsHyperpolarized MR spectroscopyImage fusionMultimodality imagingMultiparametric MRIPETProstate cancerTargeted biopsyTransrectal ultrasound

Identifiers

PMID30793241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.