ArticleJournal of chemical ecology2019
Cardenolide Intake, Sequestration, and Excretion by the Monarch Butterfly along Gradients of Plant Toxicity and Larval Ontogeny.
Article in Journal of chemical ecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Host plant specificity of the monarch butterfly Danaus plexippus: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Ontogenetic shifts in the metabolomic profiles of Battus polydamas (Lepidoptera: Papilionidae: Troidini) Feeding on Aristolochia gigantea.Journal of chemical ecology · 2026Article
- Article
- Divergent dietary and defensive adaptations of closely related coexisting seed bugs.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Selective Sequestration of Cardenolides Shapes Chemical Defense in an Aposematic Butterfly.Journal of chemical ecology · 2026Review
- Regurgitation of locusts dedicates chemical defense against predators.Science China. Life sciences · 2026Article
- Genomic basis of adaptation to cardiac glycosides in three insect orders.Frontiers in genetics · 2026Article
- Common grass blue butterflies (Zizina otis) are toxic throughout their geographic range.The Journal of experimental biology · 2025Article
- Regionality and Temporal Dynamics of Sequestration and Relocation of Cardenolides in the Monarch Butterfly, Danaus plexippus.Journal of chemical ecology · 2025Article
- Plant chemical diversity enhances defense against herbivory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cardenolides in the defensive fluid of adult large milkweed bugs have differential potency on vertebrate and invertebrate predator NaRoyal Society open science · 2024Article
- Mixtures of Milkweed Cardenolides Protect Monarch Butterflies against Parasites.Journal of chemical ecology · 2024Article
- A nutrition-defence trade-off drives diet choice in a toxic plant generalist.Proceedings. Biological sciences · 2023Article
- The price of defence: toxins, visual signals and oxidative state in an aposematic butterfly.Proceedings. Biological sciences · 2023Article
- Phytochemical and Biological Study of Trophic Interaction betweenPlants (Basel, Switzerland) · 2023Article
- New Structures, Spectrometric Quantification, and Inhibitory Properties of Cardenolides fromMolecules (Basel, Switzerland) · 2022Article
- Molecular Networking and On-Tissue Chemical Derivatization for Enhanced Identification and Visualization of Steroid Glycosides by MALDI Mass Spectrometry Imaging.Analytical chemistry · 2022Article
- Impacts of larval host plant species on dispersal traits and free-flight energetics of adult butterflies.Communications biology · 2022Article
- Seasonal Variation in Host Plant Chemistry Drives Sequestration in a Specialist Caterpillar.Journal of chemical ecology · 2022Article
- Metabolization and sequestration of plant specialized metabolites in insect herbivores: Current and emerging approaches.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Monarch butterflies, Danaus plexippus, migrate long distances over which they encounter host plants that vary broadly in toxic cardenolides. Remarkably little is understood about the mechanisms of sequestration in Lepidoptera that lay eggs on host plants ranging in such toxins. Using closely-related milkweed host plants that differ more than ten-fold in cardenolide concentrations, we mechanistically address the intake, sequestration, and excretion of cardenolides by monarchs. We show that on high cardenolide plant species, adult butterflies saturate in cardenolides, resulting in lower concentrations than in leaves, while on low cardenolide plants, butterflies concentrate toxins. Butterflies appear to focus their sequestration on particular compounds, as the diversity of cardenolides is highest in plant leaves, lower in frass, and least in adult butterflies. Among the variety of cardenolides produced by the plant, sequestered compounds may be less toxic to the butterflies themselves, as they are more polar on average than those in leaves. In accordance with this, results from an in vitro assay based on inhibition of Na
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.