Evidence map›Paper›PMID 30793229›Full record

ArticleVirchows Archiv : an international journal of pathology2019

Spindle cell liposarcoma with a TRIO-TERT fusion transcript.

David I Suster, Vikram Deshpande, Ivan Chebib, Martin S Taylor, John Mullen, Miriam A Bredella, G Petur Nielsen

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Molecular Characterization of Biphasic Follicular Dendritic Cell Sarcoma.Applied immunohistochemistry & molecular morphology : AIMM · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

David I SusterMassachusetts General Hospital, Department of Pathology, Harvard Medical School, Warren 2, 55 Fruit Street, Boston, MA, 02214, USA.
Vikram DeshpandeMassachusetts General Hospital, Department of Pathology, Harvard Medical School, Warren 2, 55 Fruit Street, Boston, MA, 02214, USA.
Ivan ChebibMassachusetts General Hospital, Department of Pathology, Harvard Medical School, Warren 2, 55 Fruit Street, Boston, MA, 02214, USA.
Martin S TaylorMassachusetts General Hospital, Department of Pathology, Harvard Medical School, Warren 2, 55 Fruit Street, Boston, MA, 02214, USA.
John MullenMassachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
Miriam A BredellaMassachusetts General Hospital, Department of Radiology, Harvard Medical School, Boston, MA, USA.
G Petur NielsenMassachusetts General Hospital, Department of Pathology, Harvard Medical School, Warren 2, 55 Fruit Street, Boston, MA, 02214, USA. gnielsen@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional well-differentiated, dedifferentiated, and myxoid liposarcomas have long been known to harbor numerous typical genetic alterations that allow for diagnosis of these tumors. These include MDM2 and CDK4 amplification in well-differentiated and dedifferentiated liposarcomas as well as FUS-DDIT3 rearrangements in myxoid liposarcoma. More recently, in-frame TRIO-TERT fusion genes have been described in a subset of non-translocation-related sarcomas including myxofibrosarcoma, dedifferentiated liposarcoma, undifferentiated pleomorphic sarcoma, pleomorphic rhabdomyosarcoma, and leiomyosarcoma. These genetic rearrangements lead to TERT mRNA expression levels hundreds of times higher than normal, causing increased telomerase activation in these tumors. Herein, we describe an unusual case of a liposarcoma with spindle cell features and a TRIO-TERT fusion transcript identified through next-generation sequencing.

Indexed as

AgedFemaleGene FusionGene RearrangementGuanine Nucleotide Exchange FactorsHumansLiposarcomaProtein Serine-Threonine KinasesProto-Oncogene Proteins c-mdm2SarcomaSoft Tissue NeoplasmsTelomeraseGuanine Nucleotide Exchange FactorsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-mdm2TelomeraseTERT protein, humanTRIO protein, humanFusion transcriptLiposarcomaTRIO-TERT

Identifiers

PMID30793229
OpenAlexW2918068129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.