ArticleThe European physical journal. E, Soft matter2019
First-passage time statistics of stochastic transcription process for time-dependent reaction rates.
Article in The European physical journal. E, Soft matter, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 11 citations in OpenAlex.
- A stochastic vs deterministic perspective on the timing of cellular events.Nature communications · 2024Article
- First passage time in post-transcriptional regulation by multiple small RNAs.The European physical journal. E, Soft matter · 2021Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription in gene expression is an intrinsically noisy process which involves production and degradation of mRNAs. An important quantity to describe this stochastic process is the first-passage time (FPT), i.e., the time taken by mRNAs to reach a particular threshold. The process of transcription can be modelled as a simple birth-death process, assuming that the promoter is always in an active state and to encode the stochastic environment we consider the transcription rate to be time dependent. This generalization is suitable to capture bursty mRNA dynamics usually modelled as an ON-Off model and simplifies the calculation of FPT statistics for a cell population. We study the role of periodic modulation of the transcription rate on different moments of FPT distribution of a population of cells. Our calculation shows that for sinusoidal modulation there exists an extremal value of mean FPT as a function of the time period and phase of the transcription signal. However, for the square wave modulation of transcription rates simulation results show that the extremal value of the MFPT behaves monotonically with the variation of the phase.
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