Evidence map›Paper›PMID 30793081›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2019

High-resolution data-driven model of the mouse connectome.

Joseph E Knox, Kameron Decker Harris, Nile Graddis, Jennifer D Whitesell, Hongkui Zeng, Julie A Harris, Eric Shea-Brown, Stefan Mihalas

Abstract read
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Article
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  10. The intrinsic neuronal network of the central nervous system and its modular (subsystem) architecture in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
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  14. Spectral imprint of structural embedding in effective connectivity.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph E KnoxAllen Institute for Brain Science, Seattle, Washington, USA.
Kameron Decker HarrisApplied Mathematics, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-3716-6173
Nile GraddisAllen Institute for Brain Science, Seattle, Washington, USA.
Jennifer D WhitesellAllen Institute for Brain Science, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-2961-5207
Hongkui ZengAllen Institute for Brain Science, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-0326-5878
Julie A HarrisAllen Institute for Brain Science, Seattle, Washington, USA.
Eric Shea-BrownAllen Institute for Brain Science, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-9012-1396
Stefan MihalasAllen Institute for Brain Science, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-2629-7100

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7M
Establishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1M
Mouse Cell Type-Specific Brain Mapping in Health and DiseaseR01AG047589 · NIA · ALLEN INSTITUTE · PI HARRIS, JULIE · 2014 to 2018
$3.4M
University of Washington PhD Training in Big Data for Genomics and NeuroscienceT32CA206089 · NCI · UNIVERSITY OF WASHINGTON · PI DANIEL, THOMAS L., FAIRHALL, ADRIENNE L · 2015 to 2015
$286k
NCI NIH HHS T32 CA206089NIA NIH HHS R01 AG047589NIMH NIH HHS U01 MH105982NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

Knowledge of mesoscopic brain connectivity is important for understanding inter- and intraregion information processing. Models of structural connectivity are typically constructed and analyzed with the assumption that regions are homogeneous. We instead use the Allen Mouse Brain Connectivity Atlas to construct a model of whole-brain connectivity at the scale of 100 μm voxels. The data consist of 428 anterograde tracing experiments in wild type C57BL/6J mice, mapping fluorescently labeled neuronal projections brain-wide. Inferring spatial connectivity with this dataset is underdetermined, since the approximately 2 × 10

Indexed as

ConnectomeMouseWhole-brain

Identifiers

PMID30793081
PMCPMC6372022

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.