ArticleNetwork neuroscience (Cambridge, Mass.)2019
Global connectivity of the fronto-parietal cognitive control network is related to depression symptoms in the general population.
Article in Network neuroscience (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Heterogeneous brain alterations in treatment-resistant depression converge on common control networks.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Pooled it
- Resting-state network alterations in depression: a comprehensive meta-analysis of functional connectivity.Psychological medicine · 2025Pooled it
- Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis.Molecular psychiatry · 2025Pooled it
- Reduced Brain Gray Matter Volume in Patients With First-Episode Major Depressive Disorder: A Quantitative Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Baseline electrophysiology versus oxidative metabolism as traits of inter-network differences in neurometabolic association.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence From a Large-Scale Resting-State fMRI Study.Brain and behavior · 2026Article
- Multi-Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Relationship Between Precuneus Thickness and Psychopathology in Adolescent Females With Anorexia Nervosa.The International journal of eating disorders · 2026Article
- Altered Salience-Default Mode Network Dynamics in Subclinical Depression: A Preclustering-Based Co-Activation Pattern Analysis.CNS neuroscience & therapeutics · 2026Article
- Controllability of morphometric network colocalize with underlying neurobiology in major depression.Psychological medicine · 2026Article
- Antidepressant-like effects of Ashwagandha (Withania Somnifera) on chronic unpredictable mild stress-induced depression in adolescent rats.Psychopharmacology · 2026Article
- Examining Smartphone-assessed Executive Function Metrics and Intrinsic Resting-State Functional Connectivity in Depression.Research square · 2025Article
- Identifying subtypes based on environmental and neurobiological risk and resilience factors of postpartum maternal mental health.Translational psychiatry · 2025Article
- Differences in event-related potentials between unipolar depression and bipolar II disorder during depressive episodes: a retrospective case-control study.BMC psychiatry · 2025Article
- Self-reported concussion history is not related to cortical volume in college athletes.PloS one · 2025Article
- Neuro-functional correlates of personality dimensions in Parkinson's disease.Frontiers in pharmacology · 2025Article
- Exploring the co-occurrence of depression and anxiety symptoms among Chinese vocational high school adolescents through a network approach.Frontiers in psychology · 2025Article
- Insomnia and stress: the mediating roles of frontoparietal network.Brain imaging and behavior · 2024Article
- Differences in Children and Adolescents with Depression before and after a Remediation Program: An Event-Related Potential Study.Brain sciences · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We all vary in our mental health, even among people not meeting diagnostic criteria for mental illness. Understanding this individual variability may reveal factors driving the risk for mental illness, as well as factors driving subclinical problems that still adversely affect quality of life. To better understand the large-scale brain network mechanisms underlying this variability, we examined the relationship between mental health symptoms and resting-state functional connectivity patterns in cognitive control systems. One such system is the fronto-parietal cognitive control network (FPN). Changes in FPN connectivity may impact mental health by disrupting the ability to regulate symptoms in a goal-directed manner. Here we test the hypothesis that FPN dysconnectivity relates to mental health symptoms even among individuals who do not meet formal diagnostic criteria but may exhibit meaningful symptom variation. We found that depression symptoms severity negatively correlated with between-network global connectivity (BGC) of the FPN. This suggests that decreased connectivity between the FPN and the rest of the brain is related to increased depression symptoms in the general population. These findings complement previous clinical studies to support the hypothesis that global FPN connectivity contributes to the regulation of mental health symptoms across both health and disease.
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