Evidence map›Paper›PMID 30793040›Full record

ArticleCommunications biology2019

Screening and identification of a non-peptide antagonist for the peptide hormone receptor in

Hidefumi Shinohara, Naoko Yasue, Tetsuo Onuki, Yasumitsu Kondoh, Minoru Yoshida, Yoshikatsu Matsubayashi

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Understanding the language of drugged plants.Nature chemical biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hidefumi ShinoharaDivision of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.
Naoko YasueNational Institute for Basic Biology, Myodaiji, Okazaki, 444-8585, Japan.
Tetsuo OnukiRIKEN Center for Sustainable Resource Science, Hirosawa 2-1, Wako, 351-0198, Japan.
Yasumitsu KondohRIKEN Center for Sustainable Resource Science, Hirosawa 2-1, Wako, 351-0198, Japan.
Minoru YoshidaRIKEN Center for Sustainable Resource Science, Hirosawa 2-1, Wako, 351-0198, Japan.ORCID http://orcid.org/0000-0002-4376-5674
Yoshikatsu MatsubayashiDivision of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan. matsu@bio.nagoya-u.ac.jp.
RIKEN Center for Sustainable Resource Science · JPNagoya University · JPNational Institute for Basic Biology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intercellular signaling mediated by peptide hormones and membrane-localized receptor kinases plays crucial roles in plant developmental processes. Because of their diverse functions, agonistic or antagonistic modulation of peptide signaling holds enormous promise for agricultural applications. Here we established a high-throughput screening system using a bead-immobilized receptor kinase and fluorescent-labeled peptide ligand to identify small molecules that bind peptide hormone receptors in competition with natural ligands. We used the

Indexed as

ArabidopsisArabidopsis ProteinsBinding, CompetitiveGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantHigh-Throughput Screening AssaysIntercellular Signaling Peptides and ProteinsMeristemPlant Growth RegulatorsPlant ShootsProtein BindingProtein Serine-Threonine KinasesSeedlingsSignal TransductionSmall Molecule LibrariesArabidopsis ProteinsAT1G26600 protein, ArabidopsisAT2G27250 protein, ArabidopsisBAM1 protein, ArabidopsisCLV1 protein, ArabidopsisIntercellular Signaling Peptides and ProteinsPlant Growth RegulatorsProtein Serine-Threonine KinasesSmall Molecule Libraries

Identifiers

PMID30793040
PMCPMC6377654
OpenAlexW2913134205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.