Evidence map›Paper›PMID 30793039›Full record

ArticleCommunications biology2019

CaMello-XR enables visualization and optogenetic control of G

Dennis Eickelbeck, Raziye Karapinar, Alexander Jack, Sandra T Suess, Ruxandra Barzan, Zohre Azimi, Tatjana Surdin, Michelle Grömmke, Melanie D Mark, Klaus Gerwert and 4 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  7. Synthetic surprise as the foundation of the psychedelic experience.Neuroscience and biobehavioral reviews · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Selective optogenetic control of GNature communications · 2022
    Article
  14. Article
  15. Signaling in the primary cilium through the lens of the Hedgehog pathway.Wiley interdisciplinary reviews. Developmental biology · 2020
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Dennis EickelbeckDepartment of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Raziye KarapinarDepartment of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Alexander JackDevelopmental Neurobiology, ND6/72, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.ORCID http://orcid.org/0000-0003-0183-4392
Sandra T SuessDepartment of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Ruxandra BarzanOptical Imaging Group, Institut für Neuroinformatik, NB 2/27, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Zohre AzimiOptical Imaging Group, Institut für Neuroinformatik, NB 2/27, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Tatjana SurdinDepartment of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Michelle GrömmkeDepartment of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Melanie D MarkDepartment of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Klaus GerwertDepartment of Biophysics, ND04/596, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Dirk JanckeOptical Imaging Group, Institut für Neuroinformatik, NB 2/27, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Petra WahleDevelopmental Neurobiology, ND6/72, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Katharina SpoidaDepartment of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany.
Stefan HerlitzeDepartment of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany. sxh106@gmail.com.
Ruhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The signal specificity of G protein-coupled receptors (GPCRs) including serotonin receptors (5-HT-R) depends on the trafficking and localization of the GPCR within its subcellular signaling domain. Visualizing traffic-dependent GPCR signals in neurons is difficult, but important to understand the contribution of GPCRs to synaptic plasticity. We engineered CaMello (Ca

Indexed as

Biosensing TechniquesAnimalsCalciumCerebellumCerebral CortexDependovirusElectrodes, ImplantedGene ExpressionGenetic VectorsGTP-Binding Protein alpha Subunits, Gq-G11HEK293 CellsHumansMelanopsinMiceMice, Inbred C57BLNeuronsCalciumGTP-Binding Protein alpha Subunits, Gq-G11MelanopsinReceptor, Serotonin, 5-HT2ARecombinant Fusion ProteinsRod Opsins

Identifiers

PMID30793039
PMCPMC6376006
OpenAlexW2912860407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.