ArticleBioMed research international2019
Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidney Transplantation: A Single Centre Experience.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 33 citations in OpenAlex.
- Clinical Evolution, Outcomes, and Emerging Preservation Technologies in Pancreas and Islet Transplantation.Journal of clinical medicine · 2026Review
- Advancements inFrontiers in transplantation · 2026Review
- Multiparametric ultrasound for non-invasive evaluation of kidney graft function.Journal of ultrasound · 2025Observational
- A novel risk score for predicting prolonged length of stay following pediatric kidney transplant.Pediatric nephrology (Berlin, Germany) · 2023Article
- Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review.European journal of medical research · 2023Review
- Organ Reconditioning and Machine Perfusion in Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- External pressure dynamics promote kidney viability and perfusate filtration during ex vivo kidney perfusion.Scientific reports · 2022Article
- Cancer Metabolism and Ischemia-Reperfusion Injury: Two Sides of the Same Coin.Journal of clinical medicine · 2022Review
- Contrast Enhanced Ultrasound Compared with MRI and CT in the Evaluation of Post-Renal Transplant Complications.Tomography (Ann Arbor, Mich.) · 2022Review
- Nonutilization of Kidneys From Donors After Circulatory Determinant of Death.Transplantation direct · 2022Article
- Organ Donation after Circulatory Determination of Death in India: A Joint Position Paper.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Assessing Kidney Graft Viability and Its Cells Metabolism during Machine Perfusion.International journal of molecular sciences · 2021Review
- Living Donor Kidney Transplantation Improves Graft and Recipient Survival in Patients with Multiple Kidney Transplants.Journal of clinical medicine · 2020Article
- Transplanted stem cells survive a long time: do they make you sick?Journal of the Royal Society of Medicine · 2019Article
- The Effect of Preservation Temperature on Liver, Kidney, and Pancreas Tissue ATP in Animal and Preclinical Human Models.Journal of clinical medicine · 2019Review
- Machine Perfusion for Abdominal Organ Preservation: A Systematic Review of Kidney and Liver Human Grafts.Journal of clinical medicine · 2019Review
- Organ preservation: which temperature for which organ?The Journal of international medical research · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe present our experience with hypothermic machine perfusion (HMP) versus cold storage (CS) in relation to kidney transplant outcomes.
methodsRetrospective analysis of 33 consecutive HMP kidney transplant outcomes matched with those of 33 cold stored: delayed graft function (DGF), length of hospital stay (LOS), estimated glomerular filtration rate (eGFR), and patient and graft survival were compared. Renal Resistive Indexes (RIs) during HMP in relation to DGF were also analysed.
resultsIn the HMP group, mean HMP time was 5.7 ± 3.9 hours with a mean cold ischaemic time (CIT) of 15 ± 5.6 versus 15.1 ± 5.3 hours in the CS group. DGF was lower in the HMP group (p=0.041), and donation after Circulatory Death (DCD) was a predictor for DGF (p<0.01). HMP decreased DGF in DCD grafts (p=0.036). Patient and graft survival were similar, but eGFR at 365 days was higher in the HMP cohort (p<0.001). RIs decreased during HMP (p<0.01); 2-hours RI ≥ 0.45 mmHg/mL/min predicted DGF in DCD kidneys (75% sensitivity, 80% specificity; area under the curve 0.78); 2-hours RI ≥ 0.2 mmHg/ml/min predicted DGF in DBD grafts (sensitivity 100%, specificity 91%; area under the curve 0.87).
conclusionHMP decreased DGF compared to CS, offering viability assessment pretransplant and improving one-year renal function of the grafts.
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