Evidence map›Paper›PMID 30792941›Full record

ArticlePeerJ2019

Impact of old age on resectable colorectal cancer outcomes.

Jianfei Fu, Hang Ruan, Hongjuan Zheng, Cheng Cai, Shishi Zhou, Qinghua Wang, Wenbin Chen, Wei Fu, Jinlin Du

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jianfei Fu *Department of Medical Oncology, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, P.R. China.
Hang Ruan *Department of Colorectal Surgery, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, P.R. China.
Hongjuan ZhengDepartment of Medical Oncology, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, P.R. China.
Cheng CaiDepartment of Colorectal Surgery, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, P.R. China.
Shishi ZhouDepartment of Medical Oncology, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, P.R. China.
Qinghua WangDepartment of Medical Oncology, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, P.R. China.
Wenbin ChenDepartment of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.
Wei FuDivision of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jinlin DuDepartment of Colorectal Surgery, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, P.R. China.
Zhejiang University · CNFirst Affiliated Hospital Zhejiang University · CNJohns Hopkins Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was performed to identify a reasonable cutoff age for defining older patients with colorectal cancer (CRC) and to examine whether old age was related with increased colorectal cancer-specific death (CSD) and poor colorectal cancer-specific survival (CSS).

methodsA total of 76,858 eligible patients from the surveillance, epidemiology, and end results (SEER) database were included in this study. The Cox proportional hazard regression model and the Chow test were used to determine a suitable cutoff age for defining the older group. Furthermore, a propensity score matching analysis was performed to adjust for heterogeneity between groups. A competing risk regression model was used to explore the impact of age on CSD and non-colorectal cancer-specific death (non-CSD). Kaplan-Meier survival curves were plotted to compare CSS between groups. Also, a Cox regression model was used to validate the results. External validation was performed on data from 1998 to 2003 retrieved from the SEER database.

resultsBased on a cutoff age of 70 years, the examined cohort of patients was classified into a younger group (

conclusionsA total of 70 is a suitable cutoff age to define those considered as having elderly CRC. Elderly CRC was associated with not only increased non-CSD but also with increased CSD. Further research is needed to provide evidence of whether cases of elderly CRC should receive stronger treatment if possible.

Indexed as

AgeCancer-specific deathCancer-specific survivalColorectal cancerCompeting risk regressionOldSEER

Identifiers

PMID30792941
PMCPMC6378948
OpenAlexW2914669081

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.