Evidence map›Paper›PMID 30792919›Full record

ArticleInterventional medicine & applied science2018

Insulin signaling pathway in the masseter muscle of dexamethasone-treated rats.

Igor Rabelo de França, Daniela Meneses-Santos, Gabriela Virginia Moreira, Fábio Bessa Lima, Carla Roberta de Oliveira Carvalho, Anderson Carlos Marçal

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In one paragraph

Article in Interventional medicine & applied science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Igor Rabelo de FrançaDepartment of Medicine, Center of Biological Sciences and Health, Federal University of Sergipe, Aracaju, Brazil.
Daniela Meneses-SantosDepartment of Morphology, Center of Biological Sciences and Health, Federal University of Sergipe, São Cristóvão, Brazil.
Gabriela Virginia MoreiraDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Fábio Bessa LimaDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Carla Roberta de Oliveira CarvalhoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Anderson Carlos MarçalDepartment of Morphology, Center of Biological Sciences and Health, Federal University of Sergipe, São Cristóvão, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe treatment with glucocorticoids may induce molecular changes in the level and/or degree of phosphorylation of proteins located downstream of the insulin receptor/insulin-like growth factor receptor (IR/IGF1R) in many tissues. However, few studies have investigated the intracellular insulin pathway in the masseter muscle. Therefore, this study aimed to analyze the IR/IGF1R signaling pathway in the masseter muscle of rats treated with dexamethasone. MATERIALS AND

methodsMale Wistar rats were divided into two groups: control group (intraperitoneally injected with 0.9% NaCl solution) and dexamethasone group [intraperitoneally injected with 1 mg/kg (bw) dexamethasone solution] for 10 consecutive days. Sections of the masseter muscle were removed at time zero and after the infusion of regular insulin into the portal vein.

resultsDexamethasone administration induces body weight loss without changing masseter muscle weight and reduces the expression of total IR and PI3K proteins; total levels of IRS1, Akt, and ERK1 remain unchanged between groups. The degree of phosphorylation/activity of IRS1 after insulin stimulus increased only in the control group; degree of phosphorylation of Akt increased in both groups, but this increase was attenuated in the dexamethasone group. DISCUSSION AND

conclusionThe degree of phosphorylation/activity in the masseter muscle is different from that in other muscle territories.

Indexed as

diabetes mellitusglucocorticoidsmasseter musclemasticationskeletal muscle

Identifiers

PMID30792919
PMCPMC6376360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.