ArticleGastroenterology report2019
Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in
Article in Gastroenterology report, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Whole genome sequence analysis ofiScience · 2025Article
- RdxA-independent mechanism ofFrontiers in microbiology · 2025Article
- Testing forJournal of clinical microbiology · 2024Review
- Levofloxacin+Tetracycline Quadruple Regimen for Eradication ofMiddle East journal of digestive diseases · 2023Article
- Article
- A Survey ofAntimicrobial agents and chemotherapy · 2022Article
- Automated extraction of genes associated with antibiotic resistance from the biomedical literature.Database : the journal of biological databases and curation · 2022Article
- Next-Generation Sequencing-Based Study ofMicroorganisms · 2022Article
- Characterization of Metronidazole-ResistantFrontiers in microbiology · 2022Article
- Comparison of Culture With Antibiogram to Next-Generation Sequencing Using Bacterial Isolates and Formalin-Fixed, Paraffin-Embedded Gastric Biopsies.Gastroenterology · 2021Article
- FBPAII and rpoBC, the Two Novel Secreted Proteins Identified by the Proteomic Approach from a Comparative Study between Antibiotic-Sensitive and Antibiotic-Resistant Helicobacter pylori-Associated Gastritis Strains.Infection and immunity · 2021Article
- Review
- Next Generation Sequencing for the Prediction of the Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2021Review
- Helicobacter pylori Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing.Journal of clinical microbiology · 2020Article
- Genotype profiles ofTherapeutic advances in gastroenterology · 2020Article
- A Next-Generation Sequencing-Based Approach to Identify Genetic Determinants of Antibiotic Resistance in CambodianJournal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetronidazole is one of the first-line drugs of choice in the standard triple therapy used to eradicate
methodsWe performed whole-genome sequencing on 121
resultsResistance due to RdxA truncation was identified in 34% of metronidazole-resistant strains. Analysis of core protein clusters derived from the remaining 48 metronidazole-resistant strains and 48 metronidazole-susceptible identified four variable sites significantly associated with metronidazole resistance. These sites included R16H/C in RdxA, D85N in the inner-membrane protein RclC (HP0565), V265I in a biotin carboxylase protein (HP0370) and A51V/T in a putative threonylcarbamoyl-AMP synthase (HP0918).
conclusionsOur approach identified new potential mechanisms for metronidazole resistance in
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