ArticleAntimicrobial resistance and infection control2019
Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections.
Article in Antimicrobial resistance and infection control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Discrepancy between antibiotic pack sizes and guideline recommendations: a real-world analysis based on claims data.Infection · 2025Observational
- Accordance of Registered Drug Packages with Guideline-Recommended Treatment Durations for Community-Acquired Pneumonia-A New Antibiotic Stewardship Target?Antibiotics (Basel, Switzerland) · 2024Article
- Registered Drug Packs of Antimicrobials and Treatment Guidelines for Prostatitis: Are They in Accordance?Healthcare (Basel, Switzerland) · 2022Article
- Analysing the trend over time of antibiotic consumption in the community: a tutorial on the detection of common change-points.The Journal of antimicrobial chemotherapy · 2021Article
- Predictors of physicians' intentions to use clinical practice guidelines on antimicrobial in tertiary general hospitals of China: a structural equation modeling approach.Antimicrobial resistance and infection control · 2021Article
- Implications of COVID-19 Pandemic on the Emergence of Antimicrobial Resistance: Adjusting the Response to Future Outbreaks.Life (Basel, Switzerland) · 2021Review
- Are We Making the Most of Community Pharmacies? Implementation of Antimicrobial Stewardship Measures in Community Pharmacies: A Narrative Review.Antibiotics (Basel, Switzerland) · 2021Review
- The potential negative impact of antibiotic pack on antibiotic stewardship in primary care in Switzerland: a modelling study.Antimicrobial resistance and infection control · 2020Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The aim of this study was to investigate whether marketed antibiotics package sizes are in accordance with treatment durations recommended in guidelines for prescribing antibiotics in sore throat and urinary tract infections. Methods: National drug database was searched with limitation to Antibacterials for systemic use. Formulations which did not have pre-specified dosage unit by the manufacturer were excluded (e.g. powders for oral solutions). The final list contained 94 drugs with 23 different active substances. This list was then cross-referenced with selected antimicrobial prescribing guidelines provided by Intersectoral Society for Antibiotic Resistance Control (ISKRA), National Institute for Health and Care Excellence (NICE) and The Infectious Diseases Society of America (IDSA). Results: Seven packages matched ISKRA guidelines on sore throat while 16 were mismatched. Considering drug packages under reimbursement, 3 matched ISKRA guidelines and 8 were mismatched. Only 3 packages matched IDSA guidelines for comparable indications, and 18 were mismatched. When considering NICE guidelines there were 5 mismatched and only one package that was in accordance with the guidelines. ISKRA guidelines for urinary tract infections matched 23 packages and mismatched 58 packages. IDSA guidelines for urinary tract infections matched one package and were mismatched in 15 cases. Conclusions: One of the causes of leftover antibiotics is poor accordance of antibiotic package size with treatment recommendation duration. This should be identified as a potential target for reduction of excess antibiotics in the community. Measures that promote patient adherence to therapy and patient education should be considered essential to manage proper handling of leftover antibiotics.
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