ArticleEvoDevo2019
Spatial and temporal patterns of gene expression during neurogenesis in the sea urchin
Article in EvoDevo, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Automated, high-throughput in situ hybridization of sea urchin (Lytechinus pictus) embryos.Development (Cambridge, England) · 2025Article
- Contrasting the development of larval and adult body plans during the evolution of biphasic lifecycles in sea urchins.Development (Cambridge, England) · 2024Article
- The brittle star genome illuminates the genetic basis of animal appendage regeneration.Nature ecology & evolution · 2024Article
- Identification and expression analysis of Sox family genes in echinoderms.BMC genomics · 2024Article
- Article
- Solute carrier (SLC) expression reveals skeletogenic cell diversity.Developmental biology · 2023Article
- Genome-wide identification and comparative analysis of Dmrt genes in echinoderms.Scientific reports · 2023Article
- Early expression onset of tissue-specific effector genes during the specification process in sea urchin embryos.EvoDevo · 2023Article
- microRNA-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development.Developmental neurobiology · 2023Article
- Prohibitins in neurodegeneration and mitochondrial homeostasis.Frontiers in aging · 2022Review
- Development of a larval nervous system in the sea urchin.Current topics in developmental biology · 2022Review
- The evolution of the metazoan Toll receptor family and its expression during protostome development.BMC ecology and evolution · 2021Article
- Involvement of Netrin/Unc-5 Interaction in Ciliary Beating and in Pattern Formation of the Ciliary Band-Associated Strand (CBAS) in the Sea Urchin,International journal of molecular sciences · 2020Article
- Developmental origin of peripheral ciliary band neurons in the sea urchin embryo.Developmental biology · 2020Article
- Diversity of cilia-based mechanosensory systems and their functions in marine animal behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Phylogenetic analysis and embryonic expression of panarthropod Dmrt genes.Frontiers in zoology · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe sea urchin is a basal deuterostome that is more closely related to vertebrates than many organisms traditionally used to study neurogenesis. This phylogenetic position means that the sea urchin can provide insights into the evolution of the nervous system by helping resolve which developmental processes are deuterostome innovations, which are innovations in other clades, and which are ancestral. However, the nervous system of echinoderms is one of the least understood of all major metazoan phyla. To gain insights into echinoderm neurogenesis, spatial and temporal gene expression data are essential. Then, functional data will enable the building of a detailed gene regulatory network for neurogenesis in the sea urchin that can be compared across metazoans to resolve questions about how nervous systems evolved.
resultsHere, we analyze spatiotemporal gene expression during sea urchin neurogenesis for genes that have been shown to be neurogenic in one or more species. We report the expression of 21 genes expressed in areas of neurogenesis in the sea urchin embryo from blastula stage (just before neural progenitors begin their specification sequence) through pluteus larval stage (when much of the nervous system has been patterned). Among those 21 gene expression patterns, we report expression of 11 transcription factors and 2 axon guidance genes, each expressed in discrete domains in the neuroectoderm or in the endoderm. Most of these genes are expressed in and around the ciliary band. Some including the transcription factors
conclusionsThis study builds a foundation to study how neurons are specified and evolved by analyzing spatial and temporal gene expression during neurogenesis in a basal deuterostome. With these expression patterns, we will be able to understand what genes are required for neural development in the sea urchin. These data can be used as a starting point to (1) build a spatial gene regulatory network for sea urchin neurogenesis, (2) identify how subtypes of neurons are specified, (3) perform comparative studies with the sea urchin, protostome, and vertebrate organisms.
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