Evidence map›Paper›PMID 30792750›Full record

ArticleInternational breastfeeding journal2019

Distribution of bioactive factors in human milk samples.

Reka A Vass, Agnes Kemeny, Timea Dergez, Tibor Ertl, Dora Reglodi, Adel Jungling, Andrea Tamas

Open access · goldAbstract read
In one paragraph

Article in International breastfeeding journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
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  9. [Influence of the coronavirus disease 2019 pandemic on maternal breastfeeding for very low birth weight infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
    Article
  10. Article
  11. Article
  12. Association betweenNutrients · 2022
    Article
  13. Clinical Study on Plant Galactagogue Worldwide in Promoting Women's Lactation: a Scoping Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2021
    Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Reka A Vass1Department of Anatomy, MTA-PTE PACAP Research Group, Centre for Neuroscience, Medical School, University of Pécs, Pécs, Hungary.
Agnes Kemeny2Department of Pharmacology and Pharmacotherapy; Medical School, University of Pécs, Pécs, Hungary.
Timea Dergez4Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary.
Tibor Ertl5Department of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary.
Dora Reglodi1Department of Anatomy, MTA-PTE PACAP Research Group, Centre for Neuroscience, Medical School, University of Pécs, Pécs, Hungary.
Adel Jungling1Department of Anatomy, MTA-PTE PACAP Research Group, Centre for Neuroscience, Medical School, University of Pécs, Pécs, Hungary.
Andrea Tamas1Department of Anatomy, MTA-PTE PACAP Research Group, Centre for Neuroscience, Medical School, University of Pécs, Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Breast milk provides nutrition for infants and also contains a variety of bioactive factors that influence the development of the newborn. Human milk is a complex biological fluid that can be separated into different layers (water phase and lipid phase with its component water and lipid fractions). It can affect the developing human body along the whole length of the gastrointestinal tract, and through the circulation, its factors may reach every organ. Methods: In the present study, we analyzed milk samples collected monthly for 6 months from 16 mothers from the 4 Results: We detected the presence of each bioactive factor in every layer of the milk samples during the first 6 months of breastfeeding in widespread concentration ranges. In the case of GRO, MIP-1ß, MDC, Flt-3L, fractalkine, and eotaxin, the concentrations were constant during the first 6 months of lactation. The water phase of human milk contained higher factor concentrations compared to both fractions of the lipid phase for most factors (except eotaxin and MIP-1ß). The concentrations of CD40, EGF, MCP-1, and RANTES in the first 3 months were significantly different compared to the values detected between 4 Conclusions: The novel findings of this investigation were the presence of Flt-3L and MDC in all layers of breast milk, and nearly all bioactive factors in the lipid phase. Due to their widespread physiological effects these factors may have an essential role in organogenesis.

Indexed as

AdultChemokinesCytokinesEpidermal Growth FactorFemaleHumansLactationMilk, HumanChemokinesCytokinesEpidermal Growth FactorBioactive factorsBreast milkChemokinesCytokinesFlt-3LGrowth factorLipid phaseLuminexMDCWater phase

Identifiers

PMID30792750
PMCPMC6371541
OpenAlexW2922042492

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.