Development of a MD-LC-MS/MS Method to Analyze 3 Bioactive Compounds in Huoxuezhitong Rubber Patch and Application to a Pharmacokinetic Study in Rats.

Yahua Cui, Chang Yang, Jun Liang, Linying Zhong, Caifeng Liu, Jie Bai, Shouying Du, Daofang Liu

Abstract read

In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yahua CuiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District 102488, Beijing, China.

Chang YangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District 102488, Beijing, China.

Jun LiangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District 102488, Beijing, China.

Linying ZhongSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District 102488, Beijing, China.

Caifeng LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District 102488, Beijing, China.

Jie BaiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District 102488, Beijing, China.ORCID 0000-0003-3097-5725

Shouying DuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District 102488, Beijing, China.ORCID 0000-0003-3827-3277

Daofang LiuAn Hui An Ke Yu Liang Qing Pharmaceutical Co., Ltd, Anqing 246001, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huoxuezhitong rubber patch, a well-known traditional Chinese medicine (TCM) prescription, is utilized to treat pain and inflammation. In this study, a microdialysis-ultra-high-performance liquid chromatography-tandem mass spectrometry (MD-LC-MS/MS) method was designed for the simultaneous determination of active constituents in the rubber patch, such as paeonol (Pae), eugenol (Eug), and piperine (Pip). A microdialysis probe was implanted in the subcutaneous tissue of a rat, which is intended to detect the subcutaneous concentrations of target components. Saline containing 30% ethanol acted as perfusion fluid. Analytes in the microdialysate were completely separated over an ACQITY UPLC RBEH C

Identifiers

PMID30792745

DOI10.1155/2019/6173565

PMCPMC6354162

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.