Evidence map›Paper›PMID 30792713›Full record

ArticleFrontiers in immunology2019

Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4

Laura Knop, Charlotte Frommer, Diana Stoycheva, Katrin Deiser, Ulrich Kalinke, Thomas Blankenstein, Thomas Kammertoens, Ildiko Rita Dunay, Thomas Schüler

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Laura KnopInstitute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Charlotte FrommerInstitute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Diana StoychevaInstitute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Katrin DeiserInstitute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Ulrich KalinkeTWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Medical School Hannover, Institute for Experimental Infection Research, Hannover, Germany.
Thomas BlankensteinInstitute of Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Thomas KammertoensInstitute of Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Ildiko Rita DunayInstitute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Thomas SchülerInstitute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Otto-von-Guericke University Magdeburg · DECharité - Universitätsmedizin Berlin · DECenter for Experimental and Clinical Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In lymphopenic mice, T cells become activated and undergo lymphopenia-induced proliferation (LIP). However, not all T cells are equally sensitive to lymphopenia. Several lymphopenia-insensitive T cell clones were described and their non-responsiveness was mainly attributed to clone-specific properties. Here, we provide evidence for an additional, host-dependent mechanism restraining LIP of lymphopenia-insensitive CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesCell ProliferationChronic DiseaseDendritic CellsInterferon gamma ReceptorInterleukin-6LymphopeniaMice, TransgenicReceptors, InterferonSignal TransductionInterferon gamma ReceptorInterleukin-6interleukin-6, mouseReceptors, InterferonCD4+ T cellsdendritic cellsinterferon-γlymphopenialymphopenia-induced proliferation (LIP)

Identifiers

PMID30792713
PMCPMC6374634
OpenAlexW2914925721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.