Evidence map›Paper›PMID 30792701›Full record

ArticleFrontiers in microbiology2019

Overproduction of Phospholipids by the Kennedy Pathway Leads to Hypervirulence in

Robert N Tams, Chelsi D Cassilly, Sanket Anaokar, William T Brewer, Justin T Dinsmore, Ying-Lien Chen, Jana Patton-Vogt, Todd B Reynolds

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Exometabolome variation in the fungal pathogen of humansApplied and environmental microbiology · 2026
    Article
  2. Review
  3. Review
  4. Phosphatidylcholine biosynthesis pathways inFrontiers in cellular and infection microbiology · 2025
    Article
  5. Comparative Genomic Analysis of anPolish journal of microbiology · 2024
    Article
  6. A Comprehensive Analysis of the Lipidomic Signatures inJournal of fungi (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Loss of Opi3 causes a lipid imbalance that influences the virulence traits ofFrontiers in cellular and infection microbiology · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Bilayer Forming Phospholipids as Targets for Cancer Therapy.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Article
  18. Mapping the Substrate-Binding Sites in the Phosphatidylserine Synthase inFrontiers in cellular and infection microbiology · 2021
    Article
  19. Medical mycology case reports · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Robert N TamsDepartment of Microbiology, The University of Tennessee, Knoxville, Knoxville, TN, United States.
Chelsi D CassillyDepartment of Microbiology, The University of Tennessee, Knoxville, Knoxville, TN, United States.
Sanket AnaokarDepartment of Biological Sciences, Duquesne University, Pittsburgh, PA, United States.
William T BrewerDepartment of Microbiology, The University of Tennessee, Knoxville, Knoxville, TN, United States.
Justin T DinsmoreDepartment of Microbiology, The University of Tennessee, Knoxville, Knoxville, TN, United States.
Ying-Lien ChenDepartment of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan.
Jana Patton-VogtDepartment of Biological Sciences, Duquesne University, Pittsburgh, PA, United States.
Todd B ReynoldsDepartment of Microbiology, The University of Tennessee, Knoxville, Knoxville, TN, United States.
University of Tennessee at Knoxville · USDuquesne University · USNational Taiwan University · TW

Funding

The Role of Phospholipid Turnover in Membrane Protein FunctionR15GM104876 · NIGMS · DUQUESNE UNIVERSITY · PI VOGT, JANA L · 2013 to 2024
$1.3M
Identification of CDP-DAG and serine binding sites in Candida albicans phosphatidylserine synthase, an antifungal drug targetR21AI130895 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI REYNOLDS, TODD B · 2017 to 2018
$409k
NIAID NIH HHS R21 AI130895NIGMS NIH HHS R15 GM104876
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Candida albicansCDP-DAG pathwayEPT1Kennedy pathwayPEM1PEM2phosphatidylcholinephosphatidylethanolamine

Identifiers

PMID30792701
PMCPMC6374345
OpenAlexW2911656003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.