ReviewFrontiers in endocrinology2019
Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
217 citing papers in PubMed, 8 syntheses or guidelines pooled it, 445 citations in OpenAlex.
- Maternal risk factors associated with neonatal necrotizing enterocolitis: a meta-analysis and systematic review.BMC pediatrics · 2026Pooled it
- Systematic Review: Antipsychotic Medication in Pregnancy and Neurodevelopmental Outcomes in Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Systematic evidence map on the association between exposure to personal care products and fetal growth.Environment international · 2026Pooled it
- Fetal brain development in fetal growth restriction using MRI: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- Understanding changes in echocardiographic parameters at different ages following fetal growth restriction: a systematic review and meta-analysis.American journal of physiology. Heart and circulatory physiology · 2024Pooled it
- The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction.Frontiers in pediatrics · 2024Pooled it
- Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Prenatal Amino Acid Supplementation to Improve Fetal Growth: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Can placental growth factors explain birthweight variation in offspring of women with type 1 diabetes?Diabetologia · 2021Trial
- DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia.Scientific reports · 2021Trial
- Identification of risk factors and development of a predictive model for foetal growth restriction: a retrospective case-control study.Annals of medicine · 2026Article
- Impact of altered heme oxygenase-1 in caring for preterm neonates: navigating the unknown.Pediatric research · 2026Review
- Hippocampal growth and function are reduced in the newborn following fetal growth restriction.Brain : a journal of neurology · 2026Article
- Identifying SHROOM4 as a novel X-linked susceptibility gene for cerebral palsy in Chinese males.BMC pediatrics · 2026Article
- Developmental programming in dogs.Biology of reproduction · 2026Review
- Transcriptomic Analysis ofInternational journal of molecular sciences · 2026Article
- Transcriptomic Analysis ofbioRxiv : the preprint server for biology · 2026Article
- Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia.The Journal of physiology · 2026Review
- Relationship Between Pre-Pregnancy Body Mass Index, Gestational Weight Gain, and Perinatal Outcomes Among Women Delivering at a General Hospital, Nakhon Si Thammarat Province.International journal of environmental research and public health · 2026Article
- Impact of small for gestational age on length of hospital stay and hospitalization costs in very preterm infants: a single-center retrospective cohort study.BMC pediatrics · 2026Article
157 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Being born small lays the foundation for short-term and long-term implications for life. Intrauterine or fetal growth restriction describes the pregnancy complication of pathological reduced fetal growth, leading to significant perinatal mortality and morbidity, and subsequent long-term deficits. Placental insufficiency is the principal cause of FGR, which in turn underlies a chronic undersupply of oxygen and nutrients to the fetus. The neonatal morbidities associated with FGR depend on the timing of onset of placental dysfunction and growth restriction, its severity, and the gestation at birth of the infant. In this review, we explore the pathophysiological mechanisms involved in the development of major neonatal morbidities in FGR, and their impact on the health of the infant. Fetal cardiovascular adaptation and altered organ development during gestation are principal contributors to postnatal consequences of FGR. Clinical presentation, diagnostic tools and management strategies of neonatal morbidities are presented. We also present information on the current status of targeted therapies. A better understanding of neonatal morbidities associated with FGR will enable early neonatal detection, monitoring and management of potential adverse outcomes in the newborn period and beyond.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.