Evidence map›Paper›PMID 30792692›Full record

ReviewFrontiers in endocrinology2019

Gain-of-Function Genetic Models to Study FSH Action.

Rosemary McDonald, Carolyn Sadler, T Rajendra Kumar

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rosemary McDonaldDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, IL, United States.
Carolyn SadlerDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, IL, United States.
T Rajendra KumarDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, IL, United States.
University of Colorado Anschutz Medical Campus · US

Funding

The Aging Pituitary/Gonadal AxisP01AG029531 · NIA · WICHITA STATE UNIVERSITY · PI GEORGE R BOUSFIELD · 2009 to 2026
$25.9M
Dysregulation of FSH in Obesity: Functional and Statistical AnalysisR01HD081162 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARLSON, NICHOLE, POLOTSKY, ALEX JOEL · 2015 to 2019
$1.7M
Chemoprevention of Pituitary Gondadotrope TumorsR01CA166557 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KUMAR, T. RAJENDRA · 2013 to 2017
$1.6M
Gonadal and extra-gonadal actions of FSH glycoforms in agingR56AG056046 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUMAR, T. RAJENDRA · 2017 to 2017
$481k
NCI NIH HHS R01 CA166557NIA NIH HHS P01 AG029531NIA NIH HHS R56 AG056046NICHD NIH HHS R01 HD081162
6 · The paper itself

Abstract

Follicle-stimulating hormone (FSH) is a pituitary-derived gonadotropin that plays key roles in male and female reproduction. The physiology and biochemistry of FSH have been extensively studied for many years. Beginning in the early 1990s, coincident with advances in the then emerging transgenic animal technology, and continuing till today, several gain-of-function (GOF) models have been developed to understand FSH homeostasis in a physiological context. Our group and others have generated a number of FSH ligand and receptor GOF mouse models. An FSH GOF model when combined with

Indexed as

follicle-stimulating hormoneovarypituitarytestistransgenic mice

Identifiers

PMID30792692
PMCPMC6374295
OpenAlexW2914676497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.