ArticleDose-response : a publication of International Hormesis Society
Epidemiologic Studies Cannot Reveal the True Shape of the Dose-Response Relationship for Radon-Induced Lung Cancer.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The Hormesis Concept: Strengths and Shortcomings.Biomolecules · 2023Review
- Radiation-related health hazards to uranium miners.Environmental science and pollution research international · 2020Review
- An Investigation into Indoor Radon Concentrations in Certified Passive House Homes.International journal of environmental research and public health · 2020Article
- Potential Radiological Problems in the Ukrainian War Zone and Challenges for Related Health Risks Assessments.Dose-response : a publication of International Hormesis SocietyArticle
- Radiophobia Harm, Its Main Cause, and a Proposed Solution.Dose-response : a publication of International Hormesis SocietyArticle
- Analysis of Indoor Radon Data Using Bayesian, Random Binning, and Maximum Entropy Methods.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
A long-standing controversy is the correct shape of the dose-response relationship for lung cancer induction by inhaled radon (eg, residential radon) at low levels. A probabilistic approach is used in this commentary to show that cohort and case-control epidemiologic studies cannot reveal the true shape of the dose-response relationship for radon-induced lung cancer. Using the indicated approach, it is found that while the dose response for radon-induced lung cancer is expected to be threshold-increasing, the dose-response curve for the cancer incidence when cancers caused by smoking and other carcinogens are included is expected to be threshold-decreasing (ie, threshold-hormetic), as low-level radon can protect from cancer induction by other carcinogens via stimulating the body's natural defenses against cancer. These defenses include DNA damage repair, removal of aberrant cells via apoptosis, suppression of cancer promoting inflammation, and anticancer immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.