ArticleBritish journal of cancer2019
Predictive values of colorectal cancer alarm symptoms in the general population: a nationwide cohort study.
Article in British journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 39 citations in OpenAlex.
- Digital quality measure of potentially avoidable emergency presentations among patients with colorectal cancer.BMJ quality & safety · 2026Article
- Prognostic influence of clinicopathological and laboratory factors on colorectal cancer survival in Amhara region oncology centers, retrospective cohort study, Ethiopia, 2024.Discover oncology · 2026Article
- Emergency cancer diagnosis in older adults: patterns, subgroups, and implications for health-care quality metrics.JNCI cancer spectrum · 2026Article
- Specialized healthcare diagnostic events within one year preceding colorectal cancer diagnosis.Acta oncologica (Stockholm, Sweden) · 2026Article
- Significance of Total Colonoscopy Based on the Outcome of Advanced Colorectal Cancer in Older Individuals.Asian Pacific journal of cancer prevention : APJCP · 2026Article
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- Liquid biopsy-based multi-cancer early detection: an exploration road from evidence to implementation.Science bulletin · 2025Review
- Exploring colorectal cancer patients' diagnostic pathways and general practitioners' assessment of the diagnostic processes: a Danish survey study.Scandinavian journal of primary health care · 2025Article
- Introducing colon capsule endoscopy as a new diagnostic modality for patients with bowel symptoms in general practice: a feasibility study.BMC primary care · 2025Article
- Colon Cancer General Knowledge, Attitude and Awareness Channels: A Cross-Sectional Study.Health science reports · 2025Article
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- The durability of previous examinations for cancer: Danish nationwide cohort study.Scandinavian journal of primary health care · 2024Article
- Symptom Burden and Time from Symptom Onset to Cancer Diagnosis in Patients with Early-Onset Colorectal Cancer: A Multicenter Retrospective Analysis.Current oncology (Toronto, Ont.) · 2024Article
- Neoplasia detection in FIT positive screening colonoscopies compared with an age-controlled symptomatic cohort: a retrospective review.Frontiers in gastroenterology (Lausanne, Switzerland) · 2024Article
- Colorectal Cancer Fast Tracks: Cancer Yield and the Predictive Value of Entry Criteria.Cancers · 2023Article
- Fecal occult blood and calprotectin testing to prioritize primary care patients for colonoscopy referral: The advantage study.United European gastroenterology journal · 2023Article
- Underlying cancer risk among patients with fatigue and other vague symptoms: a population-based cohort study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Role of the faecal immunochemical test in patients with risk-stratified suspected colorectal cancer symptoms: A systematic review and meta-analysis to inform the ACPGBI/BSG guidelines.The Lancet regional health. Europe · 2022Article
- Public Awareness of Colorectal Cancer Screening in the Al-Baha Region, Saudi Arabia, 2022.Cureus · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlarm symptoms are used in many cancer referral guidelines. The objectives were to determine the 1-year predictive values (PVs) of colorectal cancer (CRC) alarm symptoms in the general population and to describe the proportion of alarm symptoms reported prior to diagnosis.
methodsA nationwide prospective cohort of 69,060 individuals ≥40 years randomly selected from the Danish population was invited to complete a survey regarding symptoms and healthcare-seeking in 2012. Information on CRC diagnoses in a 12-month follow-up came from the Danish Cancer Registry. PVs and positive and negative likelihood ratios were calculated.
resultsA total of 37,455 individuals participated (response rate 54.2%). Sixty-four individuals were diagnosed with CRC. The single symptom with the highest positive PVs (PPV) and LR+ was rectal bleeding. PPVs were generally higher among individuals aged ≥75 years and highest among those reporting at least one specific alarm symptom that led to a GP contact.
conclusionIn general, the PPVs of CRC alarm symptoms are low and the NPVs high, especially in the youngest age groups. The LR + show a relative association with specific symptoms like rectal bleeding. Future campaigns on early diagnosis of CRC should focus on healthcare-seeking when experiencing rectal bleeding and target older people with the highest incidence.
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