Evidence map›Paper›PMID 30792528›Full record

ArticleScientific reports2019

Cardiac molecular pathways influenced by doxorubicin treatment in mice.

Ben F Bulten, Martina Sollini, Roberto Boni, Katrin Massri, Lioe-Fee de Geus-Oei, Hanneke W M van Laarhoven, Riemer H J A Slart, Paola A Erba

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  5. Review
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  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. [EJNMMI research · 2021
    Article
  14. Metabolic Aspects of Anthracycline Cardiotoxicity.Current treatment options in oncology · 2021
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ben F BultenDepartment of Biomedical Photonic Imaging, TechMed Centre, University of Twente, Enschede, The Netherlands. b.bulten@skbwinterswijk.nl.
Martina SolliniDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.ORCID 0000-0003-2214-6492
Roberto BoniDepartment of Nuclear Medicine, ASST Papa Giovanni XXIII, Bergamo, Italy.
Katrin MassriASST Ovest Milanese, Ospedale Legnano via Giovanni Paolo II, Legnano, Italy.
Lioe-Fee de Geus-OeiDepartment of Biomedical Photonic Imaging, TechMed Centre, University of Twente, Enschede, The Netherlands.
Hanneke W M van LaarhovenDepartment of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands.
Riemer H J A SlartDepartment of Biomedical Photonic Imaging, TechMed Centre, University of Twente, Enschede, The Netherlands.
Paola A ErbaDepartment of Nuclear Medicine, Department of Translational Research and New Technology in Medicine, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Doxorubicin (DOX) is a potent chemotherapeutic with distinct cardiotoxic properties. Understanding the underlying cardiotoxic mechanisms on a molecular level would enable the early detection of cardiotoxicity and implementation of prophylactic treatment. Our goal was to map the patterns of different radiopharmaceuticals as surrogate markers of specific metabolic pathways induced by chemotherapy. Therefore, cardiac distribution of

Indexed as

AnimalsAnnexin A5ApoptosisCardiotoxinsCaspase 3Disease Models, AnimalDoxorubicinFluorodeoxyglucose F18Gene Expression Regulation, NeoplasticHeartHumansMiceNeoplasmsOrganotechnetium CompoundsProto-Oncogene Proteins c-bcl-2RadiopharmaceuticalsAnnexin A5Bcl2 protein, mouseCardiotoxinsCasp3 protein, mouseCaspase 3DoxorubicinFluorodeoxyglucose F18Organotechnetium CompoundsProto-Oncogene Proteins c-bcl-2Radiopharmaceuticals

Identifiers

PMID30792528
PMCPMC6385261

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.