Evidence map›Paper›PMID 30792401›Full record

ArticleCell death & disease2019

Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling.

Eun-Kyoung Breuer, Daniela Fukushiro-Lopes, Annika Dalheim, Miranda Burnette, Jeremiah Zartman, Simon Kaja, Claire Wells, Loredana Campo, Kimberly J Curtis, Ricardo Romero-Moreno and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 83 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Eun-Kyoung BreuerDepartment of Radiation Oncology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA.
Daniela Fukushiro-LopesDepartment of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA.
Annika DalheimDepartment of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA.
Miranda BurnetteDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.
Jeremiah ZartmanDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.
Simon KajaDepartment of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA.
Claire WellsDivision of Cancer Studies, King's College London, Rm. 2.34 A New Hunts House, Guy's Campus, London, SE1 1 UL, UK.
Loredana CampoDepartment of Radiation Oncology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA.
Kimberly J CurtisHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Ricardo Romero-MorenoHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Laurie E LittlepageHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Glen L NieburHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.ORCID http://orcid.org/0000-0002-7134-2716
Kent HoskinsDivision of Hematology Oncology, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Michael I NishimuraDepartment of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA.
Saverio GentileDepartment of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA. sgentile@uic.edu.
Loyola University Chicago · USUniversity of Notre Dame · USKing's College London · GBUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell motility is an essential parameter of cancer metastasis. However, the role of K

Indexed as

Epithelial-Mesenchymal TransitionAnimalsAntineoplastic Agentsbeta CateninCell MovementCell ProliferationCresolsERG1 Potassium ChannelFemaleHumansMCF-7 CellsMiceNeoplasm MetastasisPhenylurea CompoundsTransplantation, HeterologousTriple Negative Breast Neoplasms1,3-bis(2-hydroxy-5-trifluoromethylphenyl)ureaAntineoplastic Agentsbeta CateninCresolsCTNNB1 protein, humanERG1 Potassium ChannelPhenylurea Compounds

Identifiers

PMID30792401
PMCPMC6385342
OpenAlexW2916929018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.