Evidence map›Paper›PMID 30792352›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Arg302 governs the pK

Natalia Grytsyk, Ana Filipa Santos Seiça, Junichi Sugihara, H Ronald Kaback, Petra Hellwig

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. AspThe Journal of biological chemistry · 2020
    Article
  2. Article
  3. Article
  4. The proton electrochemical gradient induces a kinetic asymmetry in the symport cycle of LacY.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  5. It takes two to tango: The dance of the permease.The Journal of general physiology · 2019
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Natalia GrytsykLaboratoire de Bioélectrochimie et Spectroscopie, UMR 7140, Chimie de la Matière Complexe (CMC), Université de Strasbourg, CNRS, 67081 Strasbourg, France.
Ana Filipa Santos SeiçaLaboratoire de Bioélectrochimie et Spectroscopie, UMR 7140, Chimie de la Matière Complexe (CMC), Université de Strasbourg, CNRS, 67081 Strasbourg, France.
Junichi SugiharaDepartment of Physiology, University of California, Los Angeles, CA 90095-7327.
H Ronald KabackDepartment of Physiology, University of California, Los Angeles, CA 90095-7327; rkaback@ucla.edu hellwig@unistra.fr.
Petra HellwigLaboratoire de Bioélectrochimie et Spectroscopie, UMR 7140, Chimie de la Matière Complexe (CMC), Université de Strasbourg, CNRS, 67081 Strasbourg, France; rkaback@ucla.edu hellwig@unistra.fr.ORCID 0000-0001-6294-5163
Centre National de la Recherche Scientifique · FRUniversity of California, Los Angeles · US

Funding

Dynamics of the Lactose Permease of Escherichia ColiR01GM120043 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, ERNEST M · 2016 to 2019
$1.8M
NIGMS NIH HHS R01 GM120043
6 · The paper itself

Abstract

Lactose permease is a paradigm for the major facilitator superfamily, the largest family of ion-coupled membrane transport proteins known at present. LacY carries out the coupled stoichiometric symport of a galactoside with an H

Indexed as

ArginineEscherichia coli ProteinsGlutamic AcidHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsModels, MolecularMonosaccharide Transport ProteinsMutationSpectrophotometry, InfraredSymportersArginineEscherichia coli ProteinsGlutamic AcidLacY protein, E coliMonosaccharide Transport ProteinsSymportersmembrane proteinspermeasesprotonationsurface-enhanced infrared spectroscopytransport

Identifiers

PMID30792352
PMCPMC6421430
OpenAlexW2916924068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.