ArticleScience (New York, N.Y.)2019
A pharmacological master key mechanism that unlocks the selectivity filter gate in K
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed.
- One pocket to activate them all (?): Efforts on understanding the modulator pocket in K2P channels.Channels (Austin, Tex.) · 2026Review
- Lipid gating of BK channels and activation mechanism by negatively charged lipids.Communications chemistry · 2026Article
- Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the KPharmacology research & perspectives · 2026Article
- Article
- Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease.The EMBO journal · 2026Article
- Chronic and acute modulator treatment restore wild-type-like activity and stability to the primary cystic fibrosis-causingProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Insights into the structure and modulation of human TWIK-2.Nature communications · 2026Article
- Toward the rational design of oncogenic TASK-3 channel inhibitor peptides and nanoconjugate complexes.Frontiers in pharmacology · 2026Review
- Gating modulation and potentiation of amiodarone blockage of the Kv10.1 potassium channel bu KB130015, an amiodarone derived molecule.Channels (Austin, Tex.) · 2025Article
- From Selective Permeation to Physiology in Potassium Channels.Function (Oxford, England) · 2025Review
- Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69.PLoS pathogens · 2025Article
- Atomistic mechanism of noncanonical voltage gating in KScience advances · 2025Article
- Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A PAS-targeting hERG1 activator reduces arrhythmic events in Jervell and Lange-Nielsen syndrome patient-derived hiPSC-CMs.JCI insight · 2025Article
- Computer-aided drug design for the double-membrane vesicle pore complex inhibitors against SARS-CoV-2.Frontiers in microbiology · 2025Article
- Binding kinetics of quaternary ammonium ions in Kcv potassium channels.Channels (Austin, Tex.) · 2024Article
- Isoleucine gate blocks KeLife · 2024Article
- Small Molecule NS11021 Promotes BK Channel Activation by Increasing Inner Pore Hydration.Journal of chemical information and modeling · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Marcus ScheweInstitute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de.ORCID 0000-0002-6192-5651
Han SunLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Structural Biology, 13125 Berlin, Germany.ORCID 0000-0002-1655-0838
Ümit MertInstitute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.
Alexandra MackenzieStructural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
Ashley C W PikeStructural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.ORCID 0000-0001-9661-2607
Friederike SchulzInstitute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.ORCID 0000-0002-1525-9256
Cristina ConstantinInstitute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-6788-5486
Kirsty S VowinkelInstitute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.ORCID 0000-0003-0918-4507
Linus J ConradOXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.ORCID 0000-0001-5175-1988
Aytug K KiperInstitute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.ORCID 0000-0003-2850-2523
Wendy GonzalezCentro de Bioinformatica y Simulacion Molecular, Universidad de Talca, 3465548 Talca, Chile.ORCID 0000-0002-7535-6883
Marianne MusinszkiInstitute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.ORCID 0000-0002-5597-6735
Marie TegtmeierInstitute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.
David C PrydePfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, UK.ORCID 0000-0002-5767-030X
Hassane BelabedLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany.
Marc NazareLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany.ORCID 0000-0002-1602-2330
Bert L de GrootComputational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.ORCID 0000-0003-3570-3534
Niels DecherInstitute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.ORCID 0000-0001-8892-1231
Bernd FaklerInstitute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.
Elisabeth P CarpenterStructural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.ORCID 0000-0001-9138-2937
Stephen J TuckerOXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.ORCID 0000-0001-8996-2000
Thomas BaukrowitzInstitute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de.
Funding
Wellcome Trust 109114
Abstract
Potassium (K
Indexed as
AnimalsChlorobenzenesCHO CellsCricetulusCrystallography, X-RayDrug DesignERG1 Potassium ChannelHEK293 CellsHumansIon Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsMolecular Dynamics Simulationortho-AminobenzoatesProtein DomainsTetrahydronaphthalenesTetrazoles1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thiourea2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid(5,6,7,8-tetrahydronaphthalen-1-yl)-(2-(1H-tetrazol-5-yl)phenyl)amineChlorobenzenesERG1 Potassium ChannelKCNH2 protein, humanLarge-Conductance Calcium-Activated Potassium Channelsortho-AminobenzoatesTetrahydronaphthalenesTetrazolesThiourea
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.