Evidence map›Paper›PMID 30792272›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.

Karen M J van Loo, Christine K Rummel, Julika Pitsch, Johannes Alexander Müller, Arthur F Bikbaev, Erick Martinez-Chavez, Sandra Blaess, Dirk Dietrich, Martin Heine, Albert J Becker and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pathophysiological Roles of Auxiliary Calcium Channel αHandbook of experimental pharmacology · 2023
    Article
  9. αInternational journal of molecular sciences · 2022
    Article
  10. Article
  11. Article
  12. Presynaptic αProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Neuronal αPflugers Archiv : European journal of physiology · 2020
    Review
  18. CaAdvances in cancer research · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Karen M J van LooSection for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany, Karen.van_loo@ukb.uni-bonn.de.ORCID 0000-0003-3074-5612
Christine K RummelSection for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany.
Julika PitschSection for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany.ORCID 0000-0002-6688-4916
Johannes Alexander MüllerSection for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany.ORCID 0000-0002-5578-6405
Arthur F BikbaevRG Molecular Physiology, Leibniz Institute for Neurobiology, Center for Behavioral Brain Science, Otto-von-Guericke-University of Magdeburg, 39118 Magdeburg, Germany.
Erick Martinez-ChavezInstitute of Reconstructive Neurobiology, University of Bonn Medical Center, 53105 Bonn, Germany, and.ORCID 0000-0003-4870-8377
Sandra BlaessInstitute of Reconstructive Neurobiology, University of Bonn Medical Center, 53105 Bonn, Germany, and.
Dirk DietrichDepartment of Neurosurgery, University of Bonn Medical Center, 53105 Bonn, Germany.
Martin HeineRG Molecular Physiology, Leibniz Institute for Neurobiology, Center for Behavioral Brain Science, Otto-von-Guericke-University of Magdeburg, 39118 Magdeburg, Germany.
Albert J BeckerSection for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany.
Susanne SchochSection for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany.ORCID 0000-0002-2046-2670
University of Bonn · DECenter for Behavioral Brain Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient brain insults, including status epilepticus (SE), can trigger a period of epileptogenesis during which functional and structural reorganization of neuronal networks occurs resulting in the onset of focal epileptic seizures. In recent years, mechanisms that regulate the dynamic transcription of individual genes during epileptogenesis and thereby contribute to the development of a hyperexcitable neuronal network have been elucidated. Our own results have shown early growth response 1 (Egr1) to transiently increase expression of the T-type voltage-dependent Ca

Indexed as

AnimalsCalcium ChannelsDisease Models, AnimalEarly Growth Response Protein 1Epilepsy, Temporal LobeHippocampusHumansKainic AcidMaleMiceNerve NetPilocarpineSeizuresStatus EpilepticusCalcium ChannelsEarly Growth Response Protein 1Egr1 protein, mouseKainic AcidPilocarpineCacna2d4CaV3.2early growth response 1epileptogenesispilocarpine and kainic acid-induced status epilepticustranscriptional Ca2+ channelopathy

Identifiers

PMID30792272
PMCPMC6788814
OpenAlexW2916913995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.