Trial reportHaematologica2019
Mode of delivery in hemophilia: vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds.
Trial report in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02979119 (The European Paediatric Network for Haemophilia Management and the PedNet Haemophilia Registry), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The European Paediatric Network for Haemophilia Management and the PedNet Haemophilia Registry
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Focus on Women with Hemophilia and Carriers: How to Address All the Existing Gaps in Diagnosis and Care.Journal of clinical medicine · 2026Review
- Maternal-fetal transfer of emicizumab in a pregnant mouse model.Blood advances · 2026Article
- Pregnancy management for patients with bleeding disorders.Hematology. American Society of Hematology. Education Program · 2025Review
- Inhibitor development and clinical characteristics in children with severe hemophilia A in the ATHN 8 US cohort study.Blood vessels, thrombosis & hemostasis · 2025Article
- Intracranial hemorrhage before start of prophylaxis in children with hemophilia: incidence, timing, and potential for prevention.Haematologica · 2025Observational
- Prenatal sonographic diagnosis and postnatal outcomes of fetal intracranial hemorrhage: Two case report.Radiology case reports · 2024Article
- Clinical and treatment characteristics of infants and toddlers less than 2 years of age with hemophilia.Blood advances · 2024Article
- Impact of Replacement Therapy on Pregnancy Outcomes in Hemophilia Carriers: A Historical Cohort Study in Saudi Arabia.Life (Basel, Switzerland) · 2024Article
- Gender equity in hemophilia: need for healthcare, familial, and societal advocacy.Frontiers in medicine · 2024Review
- Targeting the Liver with Nucleic Acid Therapeutics for the Treatment of Systemic Diseases of Liver Origin.Pharmacological reviews · 2023Review
- Management of pregnant women who have bleeding disorders.Hematology. American Society of Hematology. Education Program · 2023Article
- Bleeding disorders and postpartum hemorrhage by mode of delivery: a retrospective cohort study.Research and practice in thrombosis and haemostasis · 2023Article
- Considerations for shared decision management in previously untreated patients with hemophilia A or B.Therapeutic advances in hematology · 2023Review
- Congenital haemophilia A presenting with subgaleal and intracranial haemorrhage following instrumental delivery.BMJ case reports · 2022Article
- Managing Pregnant Women with Hemophilia and von Willebrand Disease: How Do We Provide Optimum Care and Prevent Complications?International journal of women's health · 2022Review
- Managing women-specific bleeding in inherited bleeding disorders: A multidisciplinary approach.Haemophilia : the official journal of the World Federation of Hemophilia · 2021Article
- Women with Hemophilia: Case Series of Reproductive Choices and Review of Literature.TH open : companion journal to thrombosis and haemostasis · 2021Article
- Impact of the Induction of Labor on Hemophilia Carriers and Their Newborn Infants.Journal of medical cases · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The optimal mode of delivery for a pregnant hemophilia carrier is still a matter of debate. The aim of the study was to determine the incidence of intracranial hemorrhage and other major bleeds in neonates with moderate and severe hemophilia in relationship to mode of delivery and known family history. A total of 926 neonates, 786 with severe and 140 with moderate hemophilia were included in this PedNet multicenter study. Vaginal delivery was performed in 68.3% (n=633) and Cesarean section in 31.6% (n=293). Twenty intracranial hemorrhages (2.2%) and 44 other major bleeds (4.8%) occurred. Intracranial hemorrhages occurred in 2.4% of neonates following vaginal delivery compared to 1.7% after Cesarean section (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.