Evidence map›Paper›PMID 30792196›Full record

ArticleHaematologica2019

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.

Zengdi Zhang, Zan Huang, Brianna Ong, Chinmayi Sahu, Hu Zeng, Hai-Bin Ruan

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 88 citations in OpenAlex.

  1. Youthfulness of marrow AdipoqBone research · 2026
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  13. Bone marrow adipocytes: key players in vascular niches, aging, and disease.Frontiers in cell and developmental biology · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zengdi ZhangDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Zan HuangDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Brianna OngDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Chinmayi SahuDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Hu ZengDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Hai-Bin RuanDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA hruan@umn.edu.
University of Minnesota Medical Center · USMayo Clinic in Arizona · US

Funding

Protein O-GlcNAcylation in Regulatory T Cell FunctionR01AI139420 · NIAID · UNIVERSITY OF MINNESOTA · PI RUAN, HAI-BIN · 2019 to 2023
$2.3M
O-GlcNAc signaling enables the intestinal epithelial remodeling associated with type 2 immunityR21AI140109 · NIAID · UNIVERSITY OF MINNESOTA · PI RUAN, HAI-BIN · 2018 to 2019
$424k
NIAID NIH HHS R01 AI139420NIAID NIH HHS R21 AI140109
6 · The paper itself

Abstract

Hematopoiesis is dynamically regulated by metabolic cues in homeostatic and stressed conditions; however, the cellular and molecular mechanisms mediating the metabolic sensing and regulation remain largely obscure. Bone marrow adipose tissue remodels in various metabolic conditions and has been recently proposed as a niche for hematopoietic stem cells after irradiation. Here, we investigated the role of marrow adipose tissue-derived hematopoietic cytokine stem cell factor in unperturbed hematopoiesis by selectively ablating the

Indexed as

HematopoiesisAdipocytesAdiponectinAdipose TissueAnimalsBone MarrowBone Marrow CellsCytokinesDiet, High-FatFemaleMaleMiceMice, KnockoutPhenotypeReceptors, Adrenergic, beta-3Sp7 Transcription FactorAdiponectinAdipoq protein, mouseCytokinesReceptors, Adrenergic, beta-3Sp7 protein, mouseSp7 Transcription FactorStem Cell Factor

Identifiers

PMID30792196
PMCPMC6717592
OpenAlexW2915844120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.