Evidence map›Paper›PMID 30791981›Full record

ArticleBiochemical and biophysical research communications2019

LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors.

Yan-Lin Fu, Bin Zhang, Ting-Wei Mu

Abstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

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  12. 5-HTInternational journal of molecular sciences · 2023
    Article
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  17. Defining the ligand-dependent proximatome of the sigma 1 receptor.Frontiers in cell and developmental biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yan-Lin FuDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Bin ZhangGenomic Medicine Institute, Lerner Research Institute of Cleveland Clinic, Cleveland, OH, USA.
Ting-Wei MuDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: tingwei.mu@case.edu.
University School · USCleveland Clinic Lerner College of Medicine · US

Funding

ER-to-Golgi transport of coagulation factors V and VIIIR01HL094505 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZHANG, BIN · 2009 to 2022
$5.1M
Understanding GABAA receptor protein folding and misfoldingR01NS105789 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Tingwei Mu · 2018 to 2026
$3.9M
LMAN1 mutations in colorectal cancer developmentR03CA202131 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZHANG, BIN · 2017 to 2018
$159k
NCI NIH HHS R03 CA202131NHLBI NIH HHS R01 HL094505NINDS NIH HHS R01 NS105789
6 · The paper itself

Abstract

The endoplasmic reticulum-Golgi intermediate compartment protein-53 (ERGIC-53, aka LMAN1), which cycles between the endoplasmic reticulum (ER) and Golgi, is a known cargo receptor for a number of soluble proteins. However, whether LMAN1 plays a role as a trafficking factor in the central nervous system is largely unknown. Here, we determined the role of LMAN1 on endogenous protein levels of the Cys-loop superfamily of neuroreceptors, including gamma-aminobutyric acid type A receptors (GABA

Indexed as

AnimalsBrainCell LineHumansMannose-Binding LectinsMembrane ProteinsMiceMice, KnockoutProtein TransportReceptors, GABA-AReceptors, Serotonin, 5-HT3Sensory Receptor CellsERGIC-53 protein, mouseMannose-Binding LectinsMembrane ProteinsReceptors, GABA-AReceptors, Serotonin, 5-HT3Cys-loop receptorsERP44GABA(A)RsLMAN1

Identifiers

PMID30791981
PMCPMC6431259
OpenAlexW2915760081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.