Evidence map›Paper›PMID 30791910›Full record

ArticleBMC complementary and alternative medicine2019

Synergistic study of a Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination on cell survival in EA.hy926 cells.

Xian Zhou, Valentina Razmovski-Naumovski, Antony Kam, Dennis Chang, Chun Guang Li, Kelvin Chan, Alan Bensoussan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Xian ZhouNICM Health Research Institute, Western Sydney University, Sydney, 2751, Australia. p.zhou@westernsydney.edu.au.ORCID http://orcid.org/0000-0001-8766-8158
Valentina Razmovski-NaumovskiNICM Health Research Institute, Western Sydney University, Sydney, 2751, Australia.
Antony KamNICM Health Research Institute, Western Sydney University, Sydney, 2751, Australia.
Dennis ChangNICM Health Research Institute, Western Sydney University, Sydney, 2751, Australia.
Chun Guang LiNICM Health Research Institute, Western Sydney University, Sydney, 2751, Australia.
Kelvin ChanNICM Health Research Institute, Western Sydney University, Sydney, 2751, Australia. k.k.chan@ljmu.ac.uk.
Alan BensoussanNICM Health Research Institute, Western Sydney University, Sydney, 2751, Australia.
Western Sydney University · AULiverpool John Moores University · GBNanyang Technological University · SGUNSW Sydney · AU

Funding

Western Sydney University Research Grant Scheme P00021202
6 · The paper itself

Abstract

backgroundThis study investigated the protective effects of the Danshen (DS) and Sanqi (SQ) herb pair on cell survival in the human cardiovascular endothelial (EA.hy926) cell line exposed to injury.

methodsNine combination ratios of Danshen-Sanqi extracts (DS-SQ) were screened for their protective effects in the EA.hy926 cell line against two different cellular impairments induced by DL-homocysteine (Hcy) - adenosine (Ado) - tumour necrosis factors (TNF) and oxidative stress (H

resultsDS-SQ ratios of 6:4 (50-300 μg/mL) produced synergistic effects (CI < 1) in restoring cell viability, reducing lactate dehydrogenase (LDH) leakage and caspase-3 expressions against Hcy-Ado-TNF. Additionally, DS-SQ 6:4 (50-150 μg/mL) was found to synergistically protect endothelial cells from impaired cellular injury induced by oxidative damage (H

conclusionsThis study provides scientific evidence to support the traditional use of the DS-SQ combination on protecting endothelial cells through their synergistic interactions.

Indexed as

Cell LineCell SurvivalDrugs, Chinese HerbalDrug SynergismHumansOxidative StressProtective AgentsReactive Oxygen SpeciesSalvia miltiorrhizadan-shen root extractDrugs, Chinese HerbalProtective AgentsReactive Oxygen SpeciessanqiCell injuryCombination indexDanshen-SanqiHomocysteineOxidative stressSynergyTumour necrosis factor

Identifiers

PMID30791910
PMCPMC6385400
OpenAlexW2917548462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.