SynthesisBMC cancer2019
Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review.
Synthesis in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- ABO blood types and head and neck cancer: a systematic review with meta-analysis of observational studies.BMJ open · 2024Pooled it
- The Association between ABO Blood Group and the Risk of Colorectal Cancer: A Systematic Literature Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2023Pooled it
- ABO Blood Groups and Its Association with Oral Cancer, Oral Potentially Malignant Disorders and Oral Submucous Fibrosis- A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2021Pooled it
- The Association Between ABO Blood Group and Preeclampsia: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Association between ABO blood groups and COVID-19 infection, severity and demise: A systematic review and meta-analysis.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Pooled it
- Clinical and Histopathological Correlations With Blood Groups in Patients With Gastric Cancer.Cureus · 2025Article
- Analysis of the correlation between ABO blood type and three bone mineral density measurements in patients with lumbar degenerative diseases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer.Scientific reports · 2025Article
- Is ABO blood type a risk factor for adjacent segment degeneration after lumbar spine fusion?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Investigation of unfavorable prognostic factors for survival in Chinese patients with gastric gastrointestinal stromal tumors.Translational cancer research · 2024Article
- Role of MiRNA in the Regulation of Blood Group Expression.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Review
- Construction and Validation of a Gastric Cancer Diagnostic Model based on Blood Groups and Tumor Markers.Journal of Cancer · 2024Article
- Novel evidence that the ABO blood group shapes erythropoiesis and results in higher hematocrit for blood group B carriers.Leukemia · 2023Article
- The prognostic value of circulating lymphocyte counts and ABO blood group in lung cancer stereotactic body radiation therapy: a retrospective study.Journal of thoracic disease · 2022Article
- Relationship between blood type and outcomes following COVID-19 infection.Seminars in vascular surgery · 2021Review
- ABO genotypes and the risk of esophageal and gastric cancers.BMC cancer · 2021Observational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe association of ABO blood groups with gastric cancer risk was proposed decades ago, but the results have been inconsistent.
methodsWe used two single nucleotide polymorphisms to determine ABO genotype in 4932 gastric cancer cases and 6158 controls of Chinese descent, and evaluated the associations of ABO blood groups and genotypes with risk of gastric cancer using multivariable logistic regression models. We also systematically reviewed published literature and performed a meta-analysis of all relevant studies.
resultsIn the case-control study, compared with blood group O, both blood group A and AB were associated with increased gastric cancer risk (for group A, odds ratio (OR) = 1.13, 95% confidence interval (CI): 1.02-1.24; for group AB, OR = 1.18, 95% CI: 1.02-1.36, respectively). Analyses of ABO genotypes revealed associations of AO and AB with risk of gastric cancer compared with OO genotype. Consistent with the case-control study, meta-analysis of 40 studies including 33,613 cases and 2,431,327 controls demonstrated that blood group A (OR = 1.19, 95% CI: 1.13-1.25) and AB (OR = 1.09, 95% CI: 1.03-1.16) were associated with increased risk of gastric cancer.
conclusionsOur analyses validated the association of blood group A with risk of gastric cancer, and suggested that blood group AB was also associated with gastric cancer risk. Functional investigations are warranted to elucidate the exact mechanism of ABO blood groups in gastric carcinogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.