Evidence map›Paper›PMID 30791740›Full record

ArticleIntegrative cancer therapies

Immunotherapy of Cancer: Developments and Reference Points, an Unorthodox Approach.

Michail Nikolaou, Georgios Nikolaou, Antonia Digklia, Christos Pontas, Nikolaos Tsoukalas, George Kyrgias, Maria Tolia

Open access · goldAbstract read
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Michail Nikolaou1 Hippokration University Hospital of Athens, Athens, Greece.ORCID 0000-0002-7215-6296
Georgios Nikolaou2 General Hospital of Nikaia, Nikaia, Piraeus, Greece.
Antonia Digklia3 CHUV, Lausanne, Switzerland.
Christos Pontas4 Evangelismos Hospital, Athens, Greece.
Nikolaos Tsoukalas5 401 General Military Hospital, Athens, Greece.
George Kyrgias6 University of Thessaly, Larissa, Greece.
Maria Tolia6 University of Thessaly, Larissa, Greece.
University of Thessaly · GR401 General Military Hospital of Athens · GREvangelismos Hospital · GRGeneral Hospital of Nikea · GRHippocration General Hospital · GRHôpital Orthopédique de la Suisse Romande · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncology is currently a sector of medical science with accelerated progress due to rapid technological development, the advancement in molecular biology, and the invention of many innovative therapies. Immunotherapy partially accounts for this advance, since it is increasingly playing an important role in the treatment of cancer patients, bringing on a sense of hope and optimism through a series of clinical studies and cases with spectacular results. Immunotherapy, after the initial successes it experienced in the early 20th century, was forgotten after chemotherapy and radiotherapy prevailed and developed slowly in the background. Today, it is the new hope for cancer treatment, despite the unorthodox path it has followed. In this article, we study the course and key points of the discovery of immune-oncology from the oncologist's point of view. We also record the questions that have been posed about immunotherapy that sometimes lead to confusion or stalemate.

Indexed as

HumansImmunotherapyMedical OncologyNeoplasmscancerColey’s toxinseconomic burden of cancerevaluation of the responsehistorical overviewimmunotherapytoxicity of immunotherapy

Identifiers

PMID30791740
PMCPMC7242802
OpenAlexW2912370183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.