Temporary Wettability Tuning of PCL/PDMS Micro Pattern Using the Plasma Treatments.

Surface wettability plays an important role in determining the function of a wound dressing. Dressings with hydrophobic surfaces are suitable for bacterial adsorption, however, a hydrophilic surface is needed to improve cell attachment for most anchorage-dependent cell types. Furthermore, the hydrophobicity/hydrophilicity of the surface can be used to direct cellular processes such as cell initial attachment, adhesion, and migration during wound healing. Thus, a surface with an ability to switch their surface wettability improves the practicality of the dressing. In this study, we propose a temporary surface wettability tuning for surface patterning utilizing plasma treatment. Polycaprolactone (PCL) and polydimethylsiloxane (PDMS) surfaces were treated with tetrafluoromethane (CF₄), sulphur hexafluoride (SF₆), and oxygen (O₂) plasma, and the effects on the surface wettability, roughness, and chemical composition were investigated. Based on the contact angle measurement, CF₄ plasma altered surface wettability of PCL and PDMS films to hydrophobic and hydrophilic, respectively. After CF₄ treatment, better attachment of primary mouse embryonic fibroblast cell (3T3) was observed on the treated PDMS surface. Embedding PCL into PDMS generated a hydrophobic-hydrophilic pattern mixture surface, which offers great potential in the tissue engineering field such as cell patterning and guidance.