ArticlePigment cell & melanoma research2019
Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl.
Article in Pigment cell & melanoma research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 19 citations in OpenAlex.
- A transcriptome analysis revealing the molecular mechanism of light intensity-driven color variation in the skin of Chinese giant salamander (Andrias davidianus).BMC genomics · 2026Article
- Embryotoxic effects of diflubenzuron active ingredient and commercial formulations: comparative insights from zebrafish model.Ecotoxicology (London, England) · 2026Article
- Melanin concentrating hormone-sleep pressure loop regulates melanin degradation through both autophagic degradation and lysosomal hydrolysis in zebrafish.The Journal of biological chemistry · 2025Article
- Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation.International journal of molecular sciences · 2022Article
- Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins inFrontiers in endocrinology · 2022Article
- Type II Opsins in the Eye, the Pineal Complex and the Skin ofFrontiers in neuroanatomy · 2021Review
- Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl.Pigment cell & melanoma research · 2019Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Different camouflages work best with some background matching colour. Our understanding of the evolution of skin colour is based mainly on the genetics of pigmentation ("background matching"), with little known about the evolution of the neuroendocrine systems that facilitate "background adaptation" through colour phenotypic plasticity. To address the latter, we studied the evolution in vertebrates of three genes, pomc, pmch and pmchl, that code for α-MSH and two melanin-concentrating hormones (MCH and MCHL). These hormones induce either dispersion/aggregation or the synthesis of pigments. We find that α-MSH is highly conserved during evolution, as is its role in dispersing/synthesizing pigments. Also conserved is the three-exon pmch gene that encodes MCH, which participates in feeding behaviours. In contrast, pmchl (known previously as pmch), is a teleost-specific intron-less gene. Our data indicate that in zebrafish, pmchl-expressing neurons extend axons to the pituitary, supportive of an MCHL hormonal role, whereas zebrafish and Xenopus pmch+ neurons send axons dorsally in the brain. The evolution of these genes and acquisition of hormonal status for MCHL explain different mechanisms used by vertebrates to background-adapt.
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