Evidence map›Paper›PMID 30791200›Full record

ReviewJournal of integrative plant biology2020

Application and future perspective of CRISPR/Cas9 genome editing in fruit crops.

Junhui Zhou, Dongdong Li, Guoming Wang, Fuxi Wang, Merixia Kunjal, Dirk Joldersma, Zhongchi Liu

Abstract readReview
In one paragraph

Review in Journal of integrative plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  4. Agrobacterium-Mediated Stable Transformation of Actinidia deliciosa (Kiwi).Methods in molecular biology (Clifton, N.J.) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junhui ZhouDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Dongdong LiDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Guoming WangDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Fuxi WangDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Merixia KunjalDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Dirk JoldersmaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Zhongchi LiuDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.

Funding

TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM008553 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MLODZIK, MAREK · 1995 to 2012
$1.6M
Maryland Agricultural Experiment Station Hatch ProjectMinistry of Education of China 201606320096Ministry of Education of China 201706850061NIGMS NIH HHS T32 GM008553NSF 1444987USDA 11889048
6 · The paper itself

Abstract

Fruit crops, including apple, orange, grape, banana, strawberry, watermelon, kiwifruit and tomato, not only provide essential nutrients for human life but also contribute to the major agricultural output and economic growth of many countries and regions in the world. Recent advancements in genome editing provides an unprecedented opportunity for the genetic improvement of these agronomically important fruit crops. Here, we summarize recent reports of applying CRISPR/Cas9 to fruit crops, including efforts to reduce disease susceptibility, change plant architecture or flower morphology, improve fruit quality traits, and increase fruit yield. We discuss challenges facing fruit crops as well as new improvements and platforms that could be used to facilitate genome editing in fruit crops, including dCas9-base-editing to introduce desirable alleles and heat treatment to increase editing efficiency. In addition, we highlight what we see as potentially revolutionary development ranging from transgene-free genome editing to de novo domestication of wild relatives. Without doubt, we now see only the beginning of what will eventually be possible with the use of the CRISPR/Cas9 toolkit. Efforts to communicate with the public and an emphasis on the manipulation of consumer-friendly traits will be critical to facilitate public acceptance of genetically engineered fruits with this new technology.

Indexed as

AllelesCRISPR-Cas SystemsCrops, AgriculturalFruitGene EditingPlants, Genetically Modified

Identifiers

PMID30791200
PMCPMC6703982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.