ArticleJournal of veterinary internal medicine2019
Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Evaluation of renal microvascular perfusion in dogs with cardiac disease using Superb Microvascular Imaging.Journal of veterinary internal medicine · 2026Article
- Serum Cystatin C and the Urinary NAG Index Identify an Altered Renal Biochemical Phenotype in Clinically Healthy Geriatric Dogs with Normal Serum Creatinine: A Three-Tier Cross-Sectional Study.Veterinary sciences · 2026Article
- Muscle Mass Is a Better Predictor of Survival in Dogs With Chronic Kidney Disease Compared to Body Condition Score.Journal of animal physiology and animal nutrition · 2026Article
- Analytical validation, reference interval determination, and diagnostic performance of plasma symmetric dimethylarginine in cattle.Journal of veterinary internal medicine · 2026Article
- Risk factors associated with elevated serum canine pancreatic lipase immunoreactivity concentration in dogs with hypercortisolism.Journal of veterinary internal medicine · 2026Article
- Analytical and Quality Control Validation of a Novel Symmetric Dimethylarginine Assay in Dogs and Cats.Veterinary clinical pathology · 2025Article
- A pilot study investigating renal biomarkers in dogs with pulmonary hypertension: a comparison between cystatin-C, symmetric dimethylarginine, and creatinine.The Journal of veterinary medical science · 2025Article
- Population pharmacokinetics modelling for clinical dose adjustment of carboplatin in dogs.BMC veterinary research · 2024Article
- Evaluation of renal function in dogs using pulsed Doppler ultrasonography.Open veterinary journal · 2024Article
- Serum symmetric dimethylarginine concentrations in enalapril- or telmisartan-treated dogs with proteinuric chronic kidney disease.Frontiers in veterinary science · 2024Article
- Prognostic value of serum cystatin C concentration in dogs with myxomatous mitral valve disease.Journal of veterinary internal medicine · 2023Article
- Biomarkers of Kidney Disease in Horses: A Review of the Current Literature.Animals : an open access journal from MDPI · 2022Review
- Assessment of serum symmetric dimethylarginine and creatinine concentrations in cats with urethral obstruction.Journal of feline medicine and surgery · 2022Article
- Molecular Mechanisms of Diabetic Kidney Disease.International journal of molecular sciences · 2022Review
- Effect of age, sex, and breed on serum cystatin C and creatinine concentrations in dogs.Veterinary research communications · 2022Article
- Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study.Veterinary sciences · 2021Article
- A Review of Specific Biomarkers of Chronic Renal Injury and Their Potential Application in Nonclinical Safety Assessment Studies.Toxicologic pathology · 2021Review
- Measurement of Selected Renal Biochemical Parameters in Healthy Adult Donkeys Considering the Influence of Gender, Age and Blood Freezing.Animals : an open access journal from MDPI · 2021Article
- Evaluation of Serum and Urine Neutrophil Gelatinase-associated Lipocalin and Cystatin C as Biomarkers of Acute Kidney Injury in Horses.Journal of veterinary research · 2021Article
- Detecting acute kidney injury in horses by measuring the concentration of symmetric dimethylarginine in serum.Acta veterinaria Scandinavica · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundEarly detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required.
objectiveTo compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection of decreased GFR in clinically stable dogs, with or without chronic kidney disease (CKD). ANIMALS: Ninety-seven client-owned dogs: 67 dogs with a diagnosis or suspicion of CKD and 30 healthy dogs were prospectively included.
methodsProspective diagnostic accuracy study. All dogs underwent physical examination, systemic arterial blood pressure measurement, urinalysis, hematology and blood biochemistry analysis, cardiac and urinary ultrasound examinations, and scintigraphy for estimation of glomerular filtration rate (mGFR). Frozen serum was used for batch analysis of SDMA and cystatin C.
resultsThe area under the curve of creatinine, SDMA, and cystatin C for detection of an mGFR <30.8 mL/min/L was 0.98 (95% confidence interval [CI], 0.93-1.0), 0.96 (95% CI, 0.91-0.99), and 0.87 (95% CI, 0.79-0.93), respectively. The sensitivity of both creatinine and SDMA at their prespecified cutoffs (115 μmol/L [1.3 mg/dL] and 14 μg/dL) for detection of an abnormal mGFR was 90%. The specificity was 90% for creatinine and 87% for SDMA. When adjusting the cutoff for cystatin C to correspond to a diagnostic sensitivity of 90% (0.49 mg/L), specificity was lower (72%) than that of creatinine and SDMA. CONCLUSIONS AND CLINICAL IMPORTANCE: Overall diagnostic performance of creatinine and SDMA for detection of decreased mGFR was similar. Overall diagnostic performance of cystatin C was inferior to both creatinine and SDMA.
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