ArticlePediatric research2019
The relationship between MMP9 and ADRA2A gene polymorphisms and mothers-newborns' nutritional status: an exploratory path model (STROBE compliant article).
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Genetic Polymorphisms Associated with Obesity in Southeast Asian Populations: A Systematic Review without Meta-Analysis.The Malaysian journal of medical sciences : MJMS · 2025Review
- Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing.International journal of molecular sciences · 2024Review
- Prebiotics, Probiotics, and Synbiotics-A Research Hotspot for Pediatric Obesity.Microorganisms · 2023Review
- Chronic Cadmium Exposure and Genetic Polymorphisms ofInternational journal of environmental research and public health · 2022Article
- Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients.Biomedicines · 2022Article
- The Yin-Yang Concept of Pediatric Obesity and Gut Microbiota.Biomedicines · 2022Review
- Transcriptome analysis reveals the potential roles of long non-coding RNAs in feed efficiency of chicken.Scientific reports · 2022Article
- Gastrodin Promotes the Survival of Random-Pattern Skin Flaps via Autophagy Flux Stimulation.Oxidative medicine and cellular longevity · 2021Article
- Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival.Frontiers in pharmacology · 2021Article
- Relationships between excessive gestational weight gain and energy and macronutrient intake in pregnant women.The Journal of international medical research · 2020Article
- Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.Frontiers in pharmacology · 2020Article
- The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography.Scientific reports · 2019Article
- Acute ischemic stroke in a 7-month-old infant, risk factors, and diagnosis peculiarities: A case report.Medicine · 2019Article
- Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.Frontiers in pharmacology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the direct effects of matrix metalloproteinase (MMP9 rs17577, MMP9 rs17576) and alfa 2 adrenergic receptor (ADRA2A rs553668) gene polymorphisms investigated in mothers and their newborns on maternal weight gain (MWG) during pregnancy and the newborn's birth weight (BW), taking into account the presence of other related factors.
methodsWe performed a cross-sectional study in 197 mother-newborn pairs in an Obstetrics Gynecology Clinic, in order to evaluate the demographic and anthropometric parameters, and gene polymorphism.
resultsBW was positively correlated with maternal age (p = 0.021) and the educational level (p = 0.002), and negatively correlated with smoking status in pregnant women (p < 0.001). The MMP9 rs17577 variant genotypes in mothers led to a lower BW (p = 0.049). The mothers with a variant genotype of ADRA2A rs553668 gene polymorphism had newborns with a higher BW (p = 0.030). MWG and gestational age (GesAge) influenced BW (p < 0.05). We noticed that newborns' variant genotype of MMP9 rs17577 was related to a significant increase in BW (p = 0.010), while the newborns who carried the variant genotype of MMP9 rs17576 expressed a negative correlation, decreasing the BW (p = 0.032).
conclusionOur study emphasizes the role of MMP9 rs17577, MMP9 rs17576, and ADRA2A rs553668 SNPs in BW determinism.
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