Evidence map›Paper›PMID 30790635›Full record

SynthesisNeuroscience and biobehavioral reviews2019

Brain alterations in children/adolescents with ADHD revisited: A neuroimaging meta-analysis of 96 structural and functional studies.

Fateme Samea, Solmaz Soluki, Vahid Nejati, Mojtaba Zarei, Samuele Cortese, Simon B Eickhoff, Masoud Tahmasian, Claudia R Eickhoff

Open access · greenAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 22 pooled it
18.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 22 syntheses or guidelines pooled it, 247 citations in OpenAlex.

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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Fateme SameaInstitute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
Solmaz SolukiInstitute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
Vahid NejatiInstitute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran; Department of Psychology, Shahid Beheshti University, Tehran, Iran.
Mojtaba ZareiInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
Samuele CorteseCenter for Innovation in Mental Health, Academic Unit of Psychology, University of Southampton, Southampton, UK; Faculty of Medicine, Clinical and Experimental Sciences (CNS and Psychiatry), University of Southampton, Southampton, UK; Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, UK; Department of Child and Adolescent Psychiatry, NYU Langone Medical Center, New York, USA.
Simon B EickhoffInstitute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1, INM-7), Research Center Jülich, Jülich, Germany.
Masoud TahmasianInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran. Electronic address: m_tahmasian@sbu.ac.ir.
Claudia R EickhoffInstitute of Neuroscience and Medicine (INM-1, INM-7), Research Center Jülich, Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Aachen, Germany.
Shahid Beheshti University · IRHeinrich Heine University Düsseldorf · DEInstitute for Cognitive Science Studies · IRUniversity of Nottingham · GB

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Meta-analysis in human brain mappingR56MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2020 to 2020
$543k
NIMH NIH HHS R01 MH074457NIMH NIH HHS R56 MH074457
6 · The paper itself

Abstract

The findings of neuroimaging studies in children/adolescents with ADHD, and even those of previous meta-analyses, are divergent. Here, Activation Likelihood Estimation meta-analysis, following the current best-practice guidelines, was conducted. We searched multiple databases and traced the references up to June 2018. Then, we extracted the reported coordinates reflecting group comparison between ADHD and healthy subjects from 96 eligible studies, containing 1914 unique participants. The analysis of pooled structural and functional, sub-analyses restricted to modality, and in-/decreased contrast did not yield any significant findings. However, further sub-analyses in the task-fMRI experiments (neutral stimuli only) led to aberrant activity in the left pallidum/putamen and decreased activity (male subjects only) in the left inferior frontal gyrus. The overall findings indicate a lack of regional convergence in children/adolescents with ADHD, which might be due to heterogeneous clinical populations, various experimental design, preprocessing, statistical procedures in individual publications. Our results highlight the need for further high-powered investigations, but may also indicate ADHD pathophysiology might rest in network interactions rather than just regional abnormality.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityBrainBrain MappingChildHumansLikelihood FunctionsMagnetic Resonance ImagingActivation likelihood estimationADHDCoordinate-based meta-analysisfMRIVBM

Identifiers

PMID30790635
PMCPMC7966818
OpenAlexW2915428382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.