Evidence map›Paper›PMID 30790237›Full record

ArticleGeneral thoracic and cardiovascular surgery2019

Intimal regeneration after coronary endarterectomy and onlay grafting in coronary artery bypass grafting.

Takayuki Okada, Naoki Minato, Shin-Ya Kanemoto, Nobuya Zempo, Kazuho Saiga, Ken Namikawa, Shohei Kanno, Hiroo Ueno

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In one paragraph

Article in General thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takayuki OkadaDepartment of Cardiovascular Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan. okada0525@gmail.com.ORCID http://orcid.org/0000-0002-9585-5292
Naoki MinatoDepartment of Cardiovascular Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Shin-Ya KanemotoDepartment of Cardiovascular Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Nobuya ZempoDepartment of Cardiovascular Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Kazuho SaigaDepartment of Stem Cell Pathology, Kansai Medical University, Osaka, Japan.
Ken NamikawaDepartment of Stem Cell Pathology, Kansai Medical University, Osaka, Japan.
Shohei KannoDepartment of Stem Cell Pathology, Kansai Medical University, Osaka, Japan.
Hiroo UenoDepartment of Stem Cell Pathology, Kansai Medical University, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCoronary onlay grafting, with or without endarterectomy, has been widely used for the treatment of diffuse lesions. Recent studies have demonstrated excellent long-term patency and favorable remodeling of onlay anastomosis; however, the underlying mechanisms remain unknown. Here, we describe the mechanism of intimal regeneration based on postmortem pathological evaluation of a patient who had undergone onlay grafting with coronary endarterectomy.

methodsThe onlay anastomosis was analyzed using a combination of immunohistological stainings, namely, H&E, vimentin, α-SMA, factor VIII, and Ki-67, to identify the source and mechanism of intimal regeneration after onlay grafting with endarterectomy.

resultsOur results suggest that the regenerated endothelium derives from the smooth muscle cells of the endarterectomized media of the coronary artery and that it circumferentially covers the internal lumen of the arterial graft.

conclusionsIntimal regeneration, derived from the smooth muscle cells of the endarterectomized coronary artery that proliferate toward the graft lumen, may be a key mechanism that underlies the observed favorable remodeling after onlay grafting during coronary endarterectomy.

Indexed as

ActinsAgedAnastomosis, SurgicalAngina PectorisBiomarkersCoronary Artery BypassCoronary VesselsEndarterectomyEndothelium, VascularFactor VIIIHumansImmunoenzyme TechniquesKi-67 AntigenMaleRegenerationSaphenous VeinACTA2 protein, humanActinsBiomarkersFactor VIIIKi-67 AntigenVimentinVIM protein, humanCoronary artery bypass graftingCoronary remodelingEndarterectomyIntimal regenerationOnlay grafting

Identifiers

PMID30790237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.