Evidence map›Paper›PMID 30790235›Full record

ArticleDermatology and therapy2019

Successful Treatment of Generalized Eruptive Keratoacanthoma of Grzybowski with Acitretin.

Hélène Mascitti, Adèle De Masson, Florence Brunet-Possenti, Jean-David Bouaziz, Pauline Laly, Nadim Mourad, Jean-Michel Garrigues, Sara Laurent-Roussel, Bénédicte Cavelier-Balloy, Isabelle Moulonguet and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dermatology and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Unique Lesions on the Dorsum of the Hands: A Quiz.Acta dermato-venereologica · 2023
    Article
  6. Interventional treatment of keratoacanthoderma: a case report.The Journal of international medical research · 2022
    Article
  7. [Syndroms associated with benign skin tumors].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Hélène MascittiDepartment of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.
Adèle De MassonDepartment of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.
Florence Brunet-PossentiINSERM UMR-1137, IAME, Department of Virology, Bichat Hospital, University of Paris 7 Paris Diderot, Paris, France.
Jean-David BouazizDepartment of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.
Pauline LalyDepartment of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.
Nadim MouradDepartment of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.
Jean-Michel GarriguesDermatology Practice, Maisons-Laffitte, France.
Sara Laurent-RousselDepartment of Pathology, Saint-Louis Hospital, AP-HP, University of Paris 7 Paris Diderot, Paris, France.
Bénédicte Cavelier-BalloyDepartment of Pathology, Saint-Louis Hospital, AP-HP, University of Paris 7 Paris Diderot, Paris, France.
Isabelle MoulonguetDepartment of Pathology, Saint-Louis Hospital, AP-HP, University of Paris 7 Paris Diderot, Paris, France.
Cristina LeschiAP-HP, Saint-Louis Hospital, Department of Pharmacogenomics, INSERM UMR-S 976, University of Paris 7 Paris Diderot, Paris, France.
Samia MourahAP-HP, Saint-Louis Hospital, Department of Pharmacogenomics, INSERM UMR-S 976, University of Paris 7 Paris Diderot, Paris, France.
Martine BagotDepartment of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.
Céleste LebbéDepartment of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.
Nicole Basset-SeguinDepartment of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France. nicole.basset-seguin@aphp.fr.
Inserm · FRUniversité Paris Cité · FRDélégation Paris 7 · FRAssistance Publique – Hôpitaux de Paris · FRMaison des Sciences de l'Homme · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKeratoacanthomas (KA) are common cutaneous skin tumors originating from the hair follicles. Unlike squamous cell carcinoma, KA can regress spontaneously and have a benign evolution. Solitary KA is the most common form but familial multiple KA (Ferguson-Smith type), genetically predisposed KA (such as in xeroderma pigmentosum, or Muir-Torre syndrome), or sporadic multiple eruptive KA (Grzybowski type) have been described. Generalized eruptive KA of Grzybowski (GEKA) is a rare condition (around 40 reported cases). The pathophysiology is still unclear. Human papillomavirus (HPV) has been detected in sporadic KA but the presence of HPV39 has never been reported, to our knowledge, in GEKA. CASE REPORT: GEKA in an 80-year-old woman was successfully treated with acitretin (0.5 mg/kg/day) combined with surgical removal of the largest lesions. Treatment was well tolerated and led to decreased pruritus and tumor regression within 6 months. The presence of HPV39 was detected in a lesion by polymerase chain reaction and Sanger sequencing. No genetic alteration was found, in particular in the genes usually altered in squamous cell carcinoma (including NOTCH1, NOTCH2, CDKN2A, TP53).

conclusionWe report a case of GEKA associated with the presence of HPV39 and the successful use of acitretin combined with surgical removal of the larger lesions.

Indexed as

AcitretinGEKAGeneralized eruptive keratoacanthoma of GrzybowskiHPVHuman papillomavirus

Identifiers

PMID30790235
PMCPMC6522604
OpenAlexW2916865641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.