ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019
No need for frame-wise attenuation correction in dynamic Rubidium-82 PET for myocardial blood flow quantification.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Downward myocardial creep during stress PET imaging is inversely associated with mortality.European journal of nuclear medicine and molecular imaging · 2024Article
- Detection and correction of patient motion in dynamicJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A preliminary evaluation of a high temporal resolution data-driven motion correction algorithm for rubidium-82 on a SiPM PET-CT system.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Value of SiPM PET in myocardial perfusion imaging using Rubidium-82.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Assessment of motion correction in dynamic rubidium-82 cardiac PET with and without frame-by-frame adjustment of attenuation maps for calculation of myocardial blood flow.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Myocardial blood flow: Is motion correction necessary?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Myocardial Creep: we can now look it in the eye without framewise PET-CT registration for myocardial blood flow quantification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegadenoson-induced stress causes a repositioning of the heart, myocardial creep, in half of the patients undergoing Rubidium-82 (Rb-82) positron emission tomography (PET). As a result, misalignment of dynamic PET and computer tomography (CT) may occur, possibly affecting CT-based attenuation correction (AC) and thereby PET-based myocardial blood flow (MBF) quantification. Our aim was to determine the need for frame-wise PET-CT AC to obtain reliable MBF measurements.
methods31 Out of 64 consecutive patients had myocardial creep during regadenoson-induced stress Rb-82 PET-CT and were included. Prior to PET image reconstruction, we applied two AC methods; single PET-CT alignment and frame-wise alignment in which PET time-frames with myocardial creep were individually co-registered with CT. The PET-CT misalignment was then quantified and MBFs for the three vascular territories and whole myocardium were calculated and compared between both methods.
resultsThe magnitude of misalignment due to myocardial creep was 13.8 ± 4.5 mm in caudal-cranial direction, 1.8 ± 2.1 mm in medial-lateral and 2.5 ± 1.8 mm in anterior-posterior direction. Frame-wise PET-CT registration did not result in different MBF measurements (P ≥ .07) and the magnitude of misalignment and MBF differences did not correlate (P ≥ .58).
conclusionThere is no need for frame-wise AC in dynamic Rb-82 PET for MBF quantification. Single alignment seems sufficient in patients with myocardial creep.
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