Evidence map›Paper›PMID 30790196›Full record

ArticleJournal of autism and developmental disorders2020

Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism.

Emily A Abel, A J Schwichtenberg, Olivia R Mannin, Kristine Marceau

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Genomic dissection of sleep archetypes in a large autism cohort.medRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emily A AbelDepartment of Human Development and Family Studies, Purdue University, 1202 West State Street, West Lafayette, IN, USA. emily.abel@yale.edu.
A J SchwichtenbergDepartment of Human Development and Family Studies, Purdue University, 1202 West State Street, West Lafayette, IN, USA.
Olivia R ManninDepartment of Human Development and Family Studies, Purdue University, 1202 West State Street, West Lafayette, IN, USA.
Kristine MarceauDepartment of Human Development and Family Studies, Purdue University, 1202 West State Street, West Lafayette, IN, USA.
State Street (United States) · US

Funding

Bio-behavioral Developmental Origins of Adolescent Substance AbuseK01DA039288 · NIDA · PURDUE UNIVERSITY · PI MARCEAU, KRISTINE · 2016 to 2020
$876k
National Institute on Drug Abuse K01 DA039288NIDA NIH HHS K01 DA039288
6 · The paper itself

Abstract

Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment, melatonin synthesis, and several genetic syndromes. An over-representation analysis identified several enriched pathways that suggest dopamine and serotonin synapses as potential shared SD and ASD mechanisms. This overlapping gene set and the highlighted biological pathways may serve as a preliminary stepping-stone for new genetic investigations of SD and ASD comorbidity.

Indexed as

Autism Spectrum DisorderAutistic DisorderCircadian RhythmComorbidityDatabases, GeneticDopamineGenetic Predisposition to DiseaseHumansMelatoninSerotoninSleep Wake DisordersDopamineMelatoninSerotoninAutism spectrum disorderCircadianGeneMelatoninSleepSyndrome

Identifiers

PMID30790196
PMCPMC6848755
OpenAlexW2916895321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.