Evidence map›Paper›PMID 30790128›Full record

ArticleIn vitro cellular & developmental biology. Animal2019

Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells.

Takashi Sekido, Shin-Ichi Nishio, Yohsuke Ohkubo, Keiko Sekido, Junichiro Kitahara, Takahide Miyamoto, Mitsuhisa Komatsu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Local problems need global solutions: The metabolic needs of regenerating organisms.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Takashi SekidoDivision of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Shin-Ichi NishioDivision of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. snishio@shinshu-u.ac.jp.ORCID http://orcid.org/0000-0003-2792-0862
Yohsuke OhkuboDivision of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Keiko SekidoDivision of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Junichiro KitaharaDivision of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Takahide MiyamotoMiyamoto Clinic, Matsumoto, 390-0841, Japan.
Mitsuhisa KomatsuDivision of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Shinshu University · JPWakamoto Pharmaceutical (Japan) · JP

Funding

Japan Society for the Promotion of Science 22591853
6 · The paper itself

Abstract

The mechanism whereby 17β-estradiol (E2) mediates insulin gene transcription has not been fully elucidated. In this study, exposure of hamster insulinoma (HIT-T15) cells to 5 × 10

Indexed as

GenomeTranscription, GeneticAnimalsBiological AssayCell LineCricetinaeEstradiolFulvestrantHumansInsulinInsulin-Secreting CellsLigandsPromoter Regions, GeneticProtein BindingProtein DomainsRatsEstradiolFulvestrantInsulinLigandsReceptors, EstrogenRNA, MessengerTamoxifenEstradiolEstrogen receptorInsulin geneRepressionTranscription

Identifiers

PMID30790128
PMCPMC6443913
OpenAlexW2917843242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.