ArticlePloS one2019
Detection of ON1 and novel genotypes of human respiratory syncytial virus and emergence of palivizumab resistance in Lebanon.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Molecular Surveillance RevealsVaccines · 2025Article
- Guideline for the diagnosis, treatment, and prevention of respiratory syncytial virus infection in children in China.Pediatric investigation · 2025Article
- Genomic Evolution and Surveillance of Respiratory Syncytial Virus during the 2023-2024 Season.Viruses · 2024Article
- Genomic characterization of circulating human respiratory syncytial viruses A and B in Kuwait using whole-genome sequencing.Microbiology spectrum · 2024Article
- Genomic characterization of respiratory syncytial virus genotypes circulating in the paediatric population of Sydney, NSW, Australia.Microbial genomics · 2023Article
- Molecular Diversity of Human Respiratory Syncytial Virus before and during the COVID-19 Pandemic in Two Neighboring Japanese Cities.Microbiology spectrum · 2023Article
- Article
- Reclassification of respiratory syncytial virus genotypes in India.Virusdisease · 2023Article
- Molecular epidemiology and clinical characteristics of respiratory syncytial virus in hospitalized children during winter 2021-2022 in Bengbu, China.Frontiers in public health · 2023Article
- ON-1 and BA-IX Are the Dominant Sub-Genotypes of Human Orthopneumovirus A&B in Riyadh, Saudi Arabia.Genes · 2022Article
- Integrated Trinity Test With RPA-CRISPR/Cas12a-Fluorescence for Real-Time Detection of Respiratory Syncytial Virus A or B.Frontiers in microbiology · 2022Article
- Molecular epidemiology of respiratory syncytial virus among children and adults in India 2016 to 2018.Virus genes · 2021Article
- Decreased human respiratory syncytial virus activity during the COVID-19 pandemic in Japan: an ecological time-series analysis.BMC infectious diseases · 2021Article
- Transmission of Respiratory Syncytial Virus genotypes in Cali, Colombia.Influenza and other respiratory viruses · 2021Article
- Article
- A three-dimensional A549 cell culture model to study respiratory syncytial virus infections.Journal of infection and public health · 2020Article
- Systematic Review of the Respiratory Syncytial Virus (RSV) Prevalence, Genotype Distribution, and Seasonality in Children from the Middle East and North Africa (MENA) Region.Microorganisms · 2020Article
- Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019Article
- A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences.Pathogens (Basel, Switzerland) · 2019Review
- Clinical and biological consequences of respiratory syncytial virus genetic diversity.Therapeutic advances in infectious diseaseReview
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory syncytial virus (RSV) is a common cause of respiratory tract infections in children and immunocompromised individuals. A multi-center surveillance of the epidemiologic and molecular characteristics of RSV circulating in Lebanon was performed. The attachment (G) and fusion (F) glycoproteins were analyzed and compared to those reported regionally and globally. 16% (83/519) of the nasopharyngeal swabs collected during the 2016/17 season tested positive for RSV; 50% (27/54) were RSV-A and 50% (27/54) were RSV-B. Phylogenetic analysis of the G glycoprotein revealed predominance of the RSVA ON1 genotype, in addition to two novel Lebanese genotype variants, hereby named LBA1 and LBA2, which descended from the ON1 and NA2 RSV-A genotypes, respectively. RSV-B strains belonged to BA9 genotype except for one BA10. Deduced amino acid sequences depicted several unique substitutions, alteration of glycosylation patterns and the emergence of palivizumab resistance among the Lebanese viruses. The emergence of ON1 and other novel genotypes that are resistant to palivizumab highlights the importance of monitoring RSV globally.
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