Evidence map›Paper›PMID 30789852›Full record

ReviewCurrent opinion in cardiology2019

Noncoding RNAs in cardiovascular diseases.

Priyatansh Gurha

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. lncRNA HOTAIR and Cardiovascular diseases.Functional & integrative genomics · 2024
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Role of NFrontiers in cardiovascular medicine · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Editorial: The Non-coding Genome and Cardiovascular Disease.Frontiers in cardiovascular medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Priyatansh GurhaCenter for Cardiovascular Genetics, Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Texas, USA.
The University of Texas Health Science Center at Houston · US

Funding

Pathogenic role of epigenetic regulator KDM5, a Histone H3 Lysine 4 demethylase in laminopathiesR21AG060413 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GURHA, PRIYATANSH · 2018 to 2019
$439k
NIA NIH HHS R21 AG060413
6 · The paper itself

Abstract

purpose of reviewHuman genome is pervasively transcribed, producing coding and noncoding RNAs. Recent studies have revealed the roles of a class of noncoding RNAs, the long noncoding RNAs (lncRNAs), in heart failure and other cardiovascular diseases. This review provides a brief summary of recent findings on lncRNA function. RECENT

findingsRecent studies have documented the roles of lncRNAs in cardiac regeneration, conduction, hypertrophy/dysfunction, and endothelial function. LncRNAs perform these functions through acting as competing RNA (by binding and sequestering MicroRNAs) or acting as guides to protein targeting. A few lncRNAs also encode small peptides (e.g., Dwarf Open Reading Frame RNA) and in the context of heart regulate cardiac calcium homeostasis. SUMMARY: Noncoding RNA provides a versatile mechanism of gene regulation and thereby present as novel targets for intervention in various cardiovascular disease. Future studies aimed at defining the context-dependent lncRNA mechanisms will be required to advance our understanding and relish the goal of RNA therapeutics.

Indexed as

Cardiovascular DiseasesMicroRNAsRNA, Long NoncodingGene Expression RegulationHumansRNA, UntranslatedMicroRNAsRNA, Long NoncodingRNA, Untranslated

Identifiers

PMID30789852
PMCPMC6459692
OpenAlexW2916775207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.