Evidence map›Paper›PMID 30789342›Full record

ArticleeLife2019

MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle.

Brian A Hodge, Xiping Zhang, Miguel A Gutierrez-Monreal, Yi Cao, David W Hammers, Zizhen Yao, Christopher A Wolff, Ping Du, Denise Kemler, Andrew R Judge and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Co-expression network analysis reveals repression ofbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. New insights into the skeletal muscle circadian clock in ruminants.Journal of animal science and biotechnology · 2026
    Review
  8. Article
  9. Article
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  11. Article
  12. Review
  13. Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  14. Review
  15. Review
  16. Review
  17. New role for cardiomyocytebioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Brian A Hodge *Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States.
Xiping Zhang *Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States.
Miguel A Gutierrez-MonrealDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, United States.
Yi CaoDepartment of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, United States.
David W HammersDepartment of Pharmacology and Therapeutics, University of Florida Health Science Center, Gainesville, United States.
Zizhen YaoAllen Institute for Brain Science, Seattle, United States.
Christopher A WolffDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, United States.
Ping DuDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, United States.
Denise KemlerDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, United States.
Andrew R JudgeDepartment of Physical Therapy, University of Florida Health Science Center, Gainesville, United States.
Karyn A EsserDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, United States.ORCID 0000-0002-5791-1441
University of Florida · USUniversity of Florida Health Science Center · USAllen Institute for Brain Science · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Muscle clock disruption accelerates the onset and progression of neurodegenerationR01AR066082 · NIAMS · UNIVERSITY OF KENTUCKY · PI ESSER, KARYN A · 2014 to 2018
$2.0M
NIAMS NIH HHS R01 AR066082NIA NIH HHS P30 AG028740NIH HHS R01AR066082
6 · The paper itself

Abstract

In the present study we show that the master myogenic regulatory factor, MYOD1, is a positive modulator of molecular clock amplitude and functions with the core clock factors for expression of clock-controlled genes in skeletal muscle. We demonstrate that MYOD1 directly regulates the expression and circadian amplitude of the positive core clock factor

Indexed as

Gene Expression RegulationAnimalsARNTL Transcription FactorsCircadian ClocksCircadian Rhythm Signaling Peptides and ProteinsCLOCK ProteinsConnectinMice, Inbred C57BLMuscle, SkeletalMyoD ProteinARNTL Transcription FactorsBmal1 protein, mouseCircadian Rhythm Signaling Peptides and ProteinsClock protein, mouseCLOCK ProteinsConnectinMyoD1 myogenic differentiation proteinMyoD ProteinTcap protein, mouseBmal1cell biologychromosomescircadian rhythmclockgene expressionmousemuscle transcription

Identifiers

PMID30789342
PMCPMC6398978
OpenAlexW2916808665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.